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Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations

机译：乙胺嘧啶可显着降低患有SOD1突变的肌萎缩性侧索硬化症患者的脑脊液Cu / Zn超氧化物歧化酶

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ObjectiveCu/Zn superoxide dismutase (SOD1) reduction prolongs survival in SOD1‐transgenic animal models. Pyrimethamine produces dose‐dependent SOD1 reduction in cell culture systems. A previous phase 1 trial showed pyrimethamine lowers SOD1 levels in leukocytes in patients with SOD1 mutations. This study investigated whether pyrimethamine lowered SOD1 levels in the cerebrospinal fluid (CSF) in patients carrying SOD1 mutations linked to familial amyotrophic lateral sclerosis (fALS/SOD1).

机译：减少铜/锌超氧化物歧化酶（SOD1）可以延长SOD1转基因动物模型的存活时间。乙胺嘧啶在细胞培养系统中产生剂量依赖性的SOD1减少。先前的一项1期试验显示，乙胺嘧啶降低了具有SOD1突变的患者白细胞中SOD1的水平。这项研究调查了乙胺嘧啶是否降低了与家族性肌萎缩性侧索硬化症（fALS / SOD1）相关的SOD1突变患者的脑脊液（CSF）中的SOD1水平。

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期刊名称 Wiley-Blackwell Online Open
作者
Dale J. Lange; Mona Shahbazi; Vincenzo Silani; Albert C. Ludolph; Jochen H. Weishaupt; Senda Ajroud‐Driss; Kara G. Fields; Rahul Remanan; Stanley H. Appel; Claudia Morelli; Alberto Doretti; Luca Maderna; Stefano Messina; Ulrike Weiland; Stefan L. Marklund; Peter M. Andersen;
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年(卷),期 -1(81),6
年度 -1
页码 837–848
总页数 12
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专利

1. Pyrimethamine Significantly Lowers Cerebrospinal Fluid Cu/Zn Superoxide Dismutase in Amyotrophic Lateral Sclerosis Patients with SOD1 Mutations [J] . Lange Dale J., Shahbazi Mona, Silani Vincenzo, Annals of neurology . 2017,第6期

机译：吡米甲胺显着降低了肌营养的侧面硬化患者的脑脊液Cu / Zn超氧化物歧化酶SOD1突变
2. Gender difference in levels of Cu/Zn superoxide dismutase (SOD1) in cerebrospinal fluid of patients with amyotrophic lateral sclerosis [J] . KATRIN FRUTIGER, THOMAS J. LUKAS, GEORGE GORRIE, Amyotrophic lateral sclerosis eofficial publication of the World Federation of Neurology Research Group on Motor Neuron Diseases . 2008,第3期

机译：肌萎缩性侧索硬化症患者脑脊液中铜/锌超氧化物歧化酶（SOD1）水平的性别差异
3. Oxidative stress and metal content in blood and cerebrospinal fluid of amyotrophic lateral sclerosis patients with and without a Cu, Zn-superoxide dismutase mutation. [J] . Ihara Y, Nobukuni K, Takata H, Neurological Research: An Interdisciplinary Quarterly Journal . 2005,第1期

机译：有和没有Cu，Zn-超氧化物歧化酶突变的肌萎缩性侧索硬化患者血液和脑脊液中的氧化应激和金属含量。
4. Identification of Three Mutations in the Cu,Zn-Superoxide Dismutase (Cu,Zn-SOD) Gene with Familial Amyotrophic Lateral Sclerosis: Transduction of Human Cu,Zn-SOD into PC12 Cells by HIV-1 TAT Protein Basic Domain [C] . CHIH-MING CHOU, CHANG-JEN HUANG, CHWEN-MING SHIH, Asian Society for Mitochondrial Research and Medicine . 2005

机译：鉴定Cu，Zn-超氧化物歧化酶（Cu，Zn-SOD）基因的三种突变与家族性肌肌疏远硬化剂：HIV-1 TAT蛋白碱性结构域的转导，Zn-SOD进入PC12细胞
5. Prion-Like Aggregation of Cu, Zn Superoxide Dismutase in Amyotrophic Lateral Sclerosis [D] . Baumer, Katelyn M. 2021

机译：铜，Zn超氧化物歧化酶在肌营养的外勒氏乳腺癌等朊病毒
6. Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis [O] . Eiichi Tokuda, Yo-ichi Takei, Shinji Ohara, 2019

机译：野生型Cu / Zn超氧化物歧化酶在散发性肌萎缩性侧索硬化的脑脊液中错折叠
7. Pyrimethamine Significantly Lowers Cerebrospinal Fluid Cu/Zn Superoxide Dismutase in Amyotrophic Lateral Sclerosis Patients with SOD1 Mutations [O] . Lange, Dale J., Shahbazi, Mona, Silani, Vincenzo, 2017

机译：乙胺嘧啶显着降低肌萎缩性侧索硬化症患者SOD1突变的脑脊液Cu / Zn超氧化物歧化酶

Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations

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