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首页> 外文期刊>Amyotrophic lateral sclerosis eofficial publication of the World Federation of Neurology Research Group on Motor Neuron Diseases >Gender difference in levels of Cu/Zn superoxide dismutase (SOD1) in cerebrospinal fluid of patients with amyotrophic lateral sclerosis
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Gender difference in levels of Cu/Zn superoxide dismutase (SOD1) in cerebrospinal fluid of patients with amyotrophic lateral sclerosis

机译：肌萎缩性侧索硬化症患者脑脊液中铜/锌超氧化物歧化酶（SOD1）水平的性别差异

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摘要

Currently the best studied mechanism for amyotrophic lateral sclerosis (ALS) is the one caused by mutations in the gene for cytosolic Cu/Zn-binding superoxide dismutase (SOD1). Mutant SOD1 protein causes motor neuron degeneration due to the gain of a novel toxic function. To evaluate the relevance of SOD1 levels in cerebrospinal fluid (CSF) in ALS patients, the SOD1 concentration was immunoassayed in the CSF of 11 patients with ALS and 19 neurological controls. The mean level of SOD1 in CSF from all samples was 45.5+/-11.3 ng/ml. There was no statistically significant difference between the levels of SOD1 in CSF of ALS patients and neurological control subjects. Here we show that the SOD1 concentration in the CSF is significantly higher in male ALS patients (54.0+/-9.0 ng/ml) compared to female ALS patients (38.1+/ -6.4 ng/ml) (p=0.007). This gender difference is not observed in the CSF of neurological controls. This is the first report of a potential gender difference in levels of SOD1 in CSF of ALS patients. Further investigation of larger sample groups is needed to determine whether it is relevant to gender related differences in disease incidence.
机译：目前，对肌萎缩性侧索硬化症（ALS）的研究最好的机制是由胞质Cu / Zn结合超氧化物歧化酶（SOD1）基因突变引起的。 SOD1突变蛋白由于获得新的毒性功能而导致运动神经元变性。为了评估ALS患者脑脊液（CSF）中SOD1水平的相关性，对11例ALS患者和19个神经系统对照的CSF中的SOD1浓度进行了免疫分析。所有样品中脑脊液中SOD1的平均水平为45.5 +/- 11.3 ng / ml。 ALS患者和神经系统控制对象的脑脊液中SOD1的含量在统计学上无显着差异。在这里，我们显示男性ALS患者（54.0 +/- 9.0 ng / ml）的CSF中SOD1浓度明显高于女性ALS患者（38.1 + / -6.4 ng / ml）（p = 0.007）。在神经控制的脑脊液中未观察到这种性别差异。这是关于ALS患者脑脊液中SOD1水平可能存在性别差异的首次报道。需要对更大的样本组进行进一步调查，以确定其是否与疾病发病率的性别相关差异有关。

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