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首页> 美国卫生研究院文献>Wiley-Blackwell Online Open >The influence of background diabetic retinopathy in the second eye on rates of progression of diabetic retinopathy between 2005 and 2010
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The influence of background diabetic retinopathy in the second eye on rates of progression of diabetic retinopathy between 2005 and 2010

机译：2005年至2010年第二只眼本底糖尿病视网膜病变对糖尿病视网膜病变进展速度的影响

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Purpose: The Gloucestershire Diabetic Eye Screening Programme offers annual digital photographic screening for diabetic retinopathy to a countywide population of people with diabetes. This study was designed to investigate progression of diabetic retinopathy in this programme of the English NHS Diabetic Eye Screening Programme.Methods: Mydriatic digital retinal photographs of people with diabetes screened on at least 2 occasions between 2005 and 2010 were graded and included in this study if the classification at first screening was no DR (R0), background DR in one (R1a) or both eyes (R1b). Times to detection of referable diabetic retinopathy (RDR) comprising maculopathy (M1), preproliferative (R2) or proliferative retinopathy (R3) were analysed using survival models.Results: Data were available on 19 044 patients, 56% men, age at screening 66 (57–74) years (median, 25th, 75th centile). A total of 8.3% of those with R1a and 28.2% of those with R1b progressed to any RDR, hazard ratios 2.9 [2.5–3.3] and 11.3 [10.0–12.8]. Similarly 7.1% and 0.11% of those with R1a progressed to M1 and R3, hazard ratios 2.7 [2.3–3.2] and 1.6 [0.5–5.0], compared to 21.8% and 1.07% of those with R1b, hazard ratio 9.1 [7.8–10.4] and 15.0 [7.1–31.5].Conclusions: The risk of progression is significantly higher for those with background DR in both eyes than those with background retinopathy in only one or in neither eye.
机译：目的：格洛斯特郡糖尿病眼科筛查计划为全县范围的糖尿病患者提供糖尿病视网膜病变的年度数字摄影筛查。该研究旨在调查英国NHS糖尿病眼筛查计划中该计划的糖尿病性视网膜病变的进展。方法：对2005年至2010年间至少两次筛查的糖尿病人散瞳的数字视网膜照片进行分级，并包括在本研究中初次筛查的分类为无DR（R0），一只（R1a）或两只眼睛（R1b）的背景DR。使用生存模型分析了包括黄斑病变（M1），增生前病变（R2）或增生性视网膜病变（R3）的糖尿病性视网膜病变（RDR）的检测时间。结果：共有19044名患者（56％的男性，筛查年龄）获得了数据66 （57-74）年（中位数，第25、75百分位数）。患有R1a者中的8.3％和患有R1b者中的28.2％进行了任何RDR，危险比分别为2.9 [2.5-3.3]和11.3 [10.0-12.8]。同样，R1a的7.1％和0.11％进入M1和R3，危险比为2.7 [2.3-3.2]和1.6 [0.5-5.0]，而R1b的分别为21.8％和1.07％，危险比为9.1 [7.8- [10.4]和15.0 [7.1–31.5]。结论：两只眼睛有背景DR的患者的发展风险显着高于一只眼睛或两只眼睛都没有背景的视网膜病变。

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