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首页> 外文期刊>Acta Pharmacologica Sinica >Sodium dimercaptopropane sulfonate as antidote against non-metallic pesticides
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Sodium dimercaptopropane sulfonate as antidote against non-metallic pesticides

机译：二巯基丙烷磺酸钠作为针对非金属农药的解毒剂

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With the advent of World War II, dimercaptol was first developed in England as an effective antidote against arsenical agents. In 1950's, scientists from the Soviet Union developed a water-soluble compound, sodium dimercaptopropane sulfonate (Na-DMPS) named as Unithiol (or Unitiol), which was able to chelate heavy metals and metalloids. Unithiol was collected in the Pharmacopeia of the Soviet Union. After a lot of efforts of scientists from several countries, this drug has been widely used in the treatment of the poisoning of heavy metals and metalloids, as a well-known specific antidote. Considering the importance of sulfhydryl groups in human body, we first initiated the possibility of sulfhydryl compounds as antidotes against some non-metal toxicants. In 1970's, they screened many sulfhydryl compounds as antidotes against acute poisoning of nereistoxin insecticides (NTXI), and found that dithiol compounds were much better than monothiol compounds in the treatment for NTXI poisoning. Na-DMPS and sodium dimercapto-succinate (Na-DMS) were among the best antidotes (Fig 1). The accumulation of experimental studies and clinical trials has confirmed that they were specific effective antidotes against NTXI. In 1990's, Na-DMPS was first applied to treat the acute poisoning of chlordimeform (CDM) an organoni-trogen insecticide, and bactericide 402, an organosulfur pesticide, and tetramine, a rodenticide. Through thorough pharmacological and toxicological studies of these non-metallic pesicides, the application of Na-DMPS as an antidote has been widened, and the development of antidotes against pesticides has been prospected. The application of Na-DMPS as an antidote against non-metallic pesticides is a successful example, which shows important theoretical basis and practical value.
机译：随着第二次世界大战的到来，二巯基丙二酮在英格兰首先被开发为一种有效的针对砷剂的解毒剂。 1950年代，苏联科学家开发了一种水溶性化合物二巯基丙烷磺酸钠（Na-DMPS），名为Unithiol（或Unitiol），它能够螯合重金属和准金属。 Unithiol收集在苏联药典中。经过来自多个国家的科学家的大量努力，该药物已作为众所周知的特定解毒剂被广泛用于治疗重金属和准金属的中毒。考虑到巯基在人体中的重要性，我们首先提出了巯基化合物作为对某些非金属毒物的解毒剂的可能性。在1970年代，他们筛选了许多巯基化合物作为神经毒素杀虫剂（NTXI）急性中毒的解毒剂，发现二硫醇化合物在治疗NTXI中毒方面比单硫醇化合物要好得多。 Na-DMPS和二巯基琥珀酸钠（Na-DMS）是最好的解毒剂之一（图1）。实验研究和临床试验的积累证实，它们是针对NTXI的特异有效解毒剂。在1990年代，Na-DMPS首次用于治疗氯胺酮（CDM）（一种有机氮杀虫剂）和杀菌剂402（一种有机硫杀虫剂）以及四胺（一种灭鼠剂）的急性中毒。通过对这些非金属农药的彻底的药理和毒理研究，已扩大了Na-DMPS作为解毒剂的应用范围，并有望开发出针对农药的解毒剂。 Na-DMPS作为非金属农药解毒剂的成功应用实例，具有重要的理论基础和实用价值。

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