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首页> 外文期刊>Acta Pharmacologica Sinica >Effect of Ginkgo biloba leaf extract on electroencephalography of rat with cerebral ischemia and reperfusion
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Effect of Ginkgo biloba leaf extract on electroencephalography of rat with cerebral ischemia and reperfusion

机译:银杏叶提取物对脑缺血再灌注大鼠脑电图的影响

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AIM: To test the effect of Ginkgo biloba leaf extract on electroencephalography (EEG) during cerebral ischemia and reperfusion. METHODS: Based on the quantitative analysis of EEG using the fast Fourier transform (FFT), the effect of Ginkgo biloba extract (GbE) on rat EEG was surveyed in the model of middle cerebral artery (MCA) occlusion and global cerebral ischemia. RESULTS: In the global cerebral ischemia, GbE 8 and 16 mg/kg could accelerate the recovery of EEG after reperfusion, and GbE 4 mg/kg had the same effect but much weaker. In the MCA occlusion model, GbE 16 and 32 mg/kg greatly suppressed the drop of power spectrum of EEG. CONCLUSION: GbE could mitigate the cerebral damage caused by ischemia.
机译:目的:检测银杏叶提取物对脑缺血再灌注过程中脑电图(EEG)的影响。方法:基于快速傅里叶变换(FFT)对脑电图的定量分析,在大脑中动脉(MCA)闭塞和全脑缺血模型中,研究了银杏叶提取物(GbE)对大鼠脑电图的影响。结果:在全球脑缺血中,GbE 8和16 mg / kg可以加速再灌注后脑电图的恢复,而GbE 4 mg / kg具有相同的作用,但作用较弱。在MCA阻塞模型中,GbE 16和32 mg / kg极大地抑制了脑电图谱的下降。结论:GbE可以减轻缺血引起的脑损伤。

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