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首页> 外文期刊>Acta Pharmacologica Sinica >Nonassociation of aryl hydrocarbon receptor genotypes with susceptibility to bladder cancer in Shanghai population
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Nonassociation of aryl hydrocarbon receptor genotypes with susceptibility to bladder cancer in Shanghai population

机译：上海人群中芳烃受体基因型与膀胱癌易感性不相关

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AIM: To assess two polymorphic forms of aryl hydrocarbon receptor (AHR) gene, G_(1721)A (R_(554)K), and G_(1768)A (V_(570)I) in Chinese population and to explore the possible association of human AHR gene polymorphism with elevated incidence of bladder cancer among Chinese Han subjects in east of China. METHODS: An allele-specific PCR-based procedure for AHR gene polymorphism genotyping was developed by this work. Genotyping on three groups of subjects in Shanghai area had been performed: a bladder cancer group with the occupational exposure to benzidine, a non-occupational bladder cancer patient group whose members lack an obvious aromatic amine exposure record, and a normal population in the same city as controls. RESULTS: A significant difference ( P < 0.01 ) in frequency distribution at locus G_(1721)A between normal population in Shanghai and a Caucasian population reported by other authors was observed. No mutant allele(A_(1768)) at locus G_(1768) A had ever been detected in our study. The observed frequencies were similar between both genders in the normal population (P = 0.54), and there were no significant difference confirmed between the case group and the control group. CONCLUSION: The locus G_(1768) of human AHR gene seems to be monomorphic among Chinese in this area. The significant distribution difference at locus G_(1721)A of human AHR gene between Chinese Han and Caucasian was confirmed. This study did not support the association of AHR G_(1721)A polymorphism with higher risk to bladder cancer among the residents in this area, either in a group of occupationally benzidine-exposed individuals or among the persons who never have an obvious aromatic amine exposure record.
机译：目的：评估中国人群中芳烃受体（AHR）基因的两种多态形式，即G_（1721）A（R_（554）K）和G_（1768）A（V_（570）I），并探讨可能的形式。 AHR基因多态性与华东地区汉族人群膀胱癌发病率升高的相关性方法：这项工作开发了基于等位基因特异性PCR的AHR基因多态性基因分型方法。对上海地区的三组受试者进行了基因分型：一个职业接触过联苯胺的膀胱癌组，一个成员没有明显的芳香胺暴露记录的非职业性膀胱癌患者组，以及同一城市的正常人群作为控件。结果：观察到上海正常人口与其他作者的白种人人口在G_（1721）A基因座频率分布存在显着差异（P <0.01）。在我们的研究中未检测到基因座G_（1768）A的突变等位基因（A_（1768））。在正常人群中，两性的观察频率相似（P = 0.54），病例组与对照组之间没有明显差异。结论：该地区华人AHR基因的基因座G_（1768）似乎是单态的。证实了中国汉族和高加索人的AHR基因位点G_（1721）A的显着分布差异。这项研究不支持该地区居民中的AHR G_（1721）A多态性与膀胱癌风险较高的相关性，无论是在一组职业性联苯胺接触人群中，还是在从未明显接触芳香胺的人群中记录。

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