目的探讨亚洲人群谷胱甘肽巯基转移酶基因 GSTM1无效基因型与膀胱癌易感性的关系。方法检索PubMed、EMBase、CBM、CNKI、VIP、万方数据平台从建库到2014年9月1日的文献,对所纳入的研究,运用 RevMan 5.2软件进行 Meta 分析。结果共纳入18篇病例对照研究,累计样本量为5992例,其中膀胱癌病例组2618例,对照组3374例。Meta分析结果可见亚洲人群中 GSTM1无效基因型与膀胱癌易感性呈显著性正相关(OR=1.48,95%CI=1.33~1.65,P<0.00001)。亚组分析提示,土耳其人群、东亚人群及中国人群中,GSTM1无效基因型均显示出能显著增加膀胱癌易感性(OR=1.31,95%CI=1.06~1.62,P=0.01；OR=1.56,95%CI=1.37~1.78,P<0.00001；OR=1.61,95%CI=1.34~1.93,P<0.00001)。漏斗图提示各文献间未见明显发表偏倚。结论在亚洲人群中 GSTM1无效基因型与膀胱癌易感性可能存在呈正相关。%Objective To explore the association between GSTM1 polymorphism and bladder cancer in Asian people. Methods Databases,including PubMed,EMBase,CBM,CNKI,VIP, Wanfang Data,were searched to get related studies.Data analysis was conducted by Revman 5 .2 software. Results Eighteen case-control studies were included.Totally ,using M-H method in the fixed-effects model,the GSTM1 null genotype was associated with bladder cancer in Asian people (OR=1.48,95%CI=1.33-1.65,P<0.000 01).In subgroup analysis,the GSTM1 null genotype was associated with bladder cancer in Turkish,East Asian and Chinese people (OR=1.31,95%CI=1.06-1.62,P=0.01;OR=1.56,95%CI=1.37-1.78,P<0.000 01;OR=1.61,95%CI=1.34-1.93,P<0.000 01).There was no existence of publication bias. Conclusions This meta-analysis suggests that there may be a rela-tionship between the GSTM1 null genotype and bladder cancer in Asian people.
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