Inhibition by nociceptin on excitatory non-adrenergic non-cholinergic response in guinea pig airways

Fang Li-Ben; Wu Yin; Zhang Li-Fan

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Inhibition by nociceptin on excitatory non-adrenergic non-cholinergic response in guinea pig airways

机译：Nociceptin对豚鼠气道兴奋性非肾上腺素能非胆碱能反应的抑制作用

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Nociceptin 0.001-0.1μmol. L~-1 inhibited the eNANC constriction which was induced By EFS but not by apsaicin in guinea pig bronchus. The constriction inhibited by NC 0.01 μmol.L~-1 was (43±31)/100compared with the control. After pretreat- ment with naloxone 0.1μmol.L~-1, the constriction was inhibited by(46±28)/100, without marked change com- pared with the above figure. Nociceptin inhibits EFS-induced ENANC constriction, which is not reversed by naloxone, While U-50488H inhibits EFS-induced eNANC response Via activation of opioid receptor in guinea pig airways.

机译：伤害感受肽0.001-0.1μmol。 L〜-1抑制了豚鼠支气管中EFS诱导的eNANC收缩，而辣椒素未诱导eNANC收缩。与对照组相比，NC 0.01μmol.L〜-1抑制的收缩率为（43±31）/ 100。用纳洛酮0.1μmol.L〜-1预处理后，收缩率被（46±28）/ 100抑制，与上图相比无明显变化。 Nociceptin抑制EFS诱导的ENANC收缩，但纳洛酮并不能逆转，而U-50488H通过激活豚鼠呼吸道中的阿片受体抑制EFS诱导的eNANC反应。

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《Acta Pharmacologica Sinica》 |2001年第6期|p.561-565|共5页
作者
Fang Li-Ben; Wu Yin; Zhang Li-Fan;
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正文语种 eng
中图分类药理学;
关键词
nociceptin; kappa opioid receptors; brtonchi;

机译：伤害感受素κ阿片受体;布雷通奇;

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专利

1. Nociceptin inhibits non-adrenergic non-cholinergic contraction in guinea-pig airway. [J] . ShahS, PageCP, SpinaD British Journal of Pharmacology . 1998,第3期

机译：伤害感受肽抑制豚鼠气道中的非肾上腺能非胆碱能收缩。
2. Nociceptin inhibits non-adrenergic non-cholinergic contraction in guinea-pig airway [J] . S.Shah, C.P.Page, D.Spina British Journal of Pharmacology . 1998,第3期

机译：伤害感受肽抑制豚鼠气道中的非肾上腺能非胆碱能收缩
3. Prejunctional modulation of non-adrenergic non-cholinergic (NANC) inhibitory responses in the isolated guinea-pig gastric fundus. [J] . Todorov S, Pozzoli C, Zamfirova R, Neurogastroenterology and motility . 2003,第3期

机译：在分离的豚鼠胃底中非肾上腺能非胆碱能（NANC）抑制反应的结前调制。
4. Effects of nociceptin, endomorphin-1 and related peptides on isolated bronchus of guinea pig [C] . Qi Yang, Cai-Yun Fu, Yong Chen, Chinese Peptide Symposium . 2005

机译：Nociceptin，Endomorphin-1和相关肽对豚鼠孤立支气管的影响
5. Neuropeptide Y Inhibits Neurogenic Inflammation in Guinea-pig Airways [D] . 高橋識至 1995

机译：神经肽Y抑制豚鼠气道神经源性炎症。
6. Inhibition of excitatory non-adrenergic non-cholinergic bronchoconstriction in guinea-pig airways in vitro by activation of an atypical 5-HT receptor. [O] . J. K. Ward, A. J. Fox, P. J. Barnes, 1994

机译：通过激活非典型的5-HT受体抑制豚鼠气道中兴奋性非肾上腺素能非胆碱能支气管收缩。
7. Inhibition of excitatory non-adrenergic non-cholinergic bronchoconstriction in guinea-pig airways in vitro by activation of an atypical 5-HT receptor. [O] . Ward, J. K., Fox, A. J., Barnes, P. J., 1994

机译：通过激活非典型的5-HT受体，抑制豚鼠气道中兴奋性非肾上腺素能非胆碱能支气管收缩。
8. Immune Response of Guinea Pigs to 'Schistosoma mansoni'. II. In Vitro Blastogenesis and Macrophage Migration Inhibition Factor Production in Response to Cercarial, Adult Worm and Egg Antigens. [R] . Chen, P., Dean, D. A. 1977

机译：豚鼠对'曼氏血吸虫'的免疫应答。 II。体外培养和巨噬细胞迁移抑制因子产生对疮痂病，成虫和卵抗原的反应。

Inhibition by nociceptin on excitatory non-adrenergic non-cholinergic response in guinea pig airways

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