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首页> 外文期刊>Acta Pharmacologica Sinica >Effects of dihydroartemisinin on fine structure of erythrocytic stages of Plasmodium berghei ANKA strain
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Effects of dihydroartemisinin on fine structure of erythrocytic stages of Plasmodium berghei ANKA strain

机译：双氢青蒿素对伯氏疟原虫ANKA菌株红细胞阶段精细结构的影响

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摘要

In P. berghei ANKA strain, 1 h after drug administration, the parasites food vacuole membranes were destroyed, and the pigment grains showed some changes. The nucleus membrane, cy- tomembrane, and food vacuole membranes were stratified 2 h after administration. At the same time, swelling and separation of the outer and inner membrane or shrinking of the mitochondria were seen. DATM was a fast-acting and effective antimalarial Drug. Its primary target is the membrane system. No Obvious resistant characteristics were found upto 24 gener- Ations after resistant induction test for 4 months.
机译：P. berghei ANKA菌株在给药1小时后，寄生虫的食物液泡膜被破坏，色素颗粒显示出一些变化。给药后2小时将细胞核膜，细胞膜和食物液泡膜分层。同时，观察到外膜和内膜的肿胀和分离或线粒体的收缩。 DATM是一种快速有效的抗疟药。其主要目标是膜系统。在进行了4个月的抗性诱导试验后，直到24个世代均未发现明显的抗性特征。

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