Individual and ethnic differences in CYP2C19 activity in Chinese populations

Shu Yan; Zhou Hong-Hao

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Individual and ethnic differences in CYP2C19 activity in Chinese populations

机译：中国人群CYP2C19活性的个体和种族差异

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Inter-individual difference in drug response is a clin- ically important problem encountered in the use of many drugs. One of its major causes is variability in the ac- tivities of drug-metabolizing enzymes of the liver. Both genetic and nongenetic factors can contribute ot the vari- ability largely. In recent years, among the drug-metabo- lizing enzymes, cytochrome P-4502C19(CYP2C19)has become a subject of extensive studies concerning individ- ual and ethnic variation in drug metabolism.

机译：药物反应的个体差异是许多药物使用中遇到的重要临床问题。其主要原因之一是肝脏药物代谢酶活性的可变性。遗传因素和非遗传因素都可以很大程度地影响变异性。近年来，在药物代谢酶中，细胞色素P-4502C19（CYP2C19）已成为有关药物代谢中个体和种族差异的广泛研究的主题。

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《Acta Pharmacologica Sinica》 |2000年第3期|p.193-199|共7页
作者
Shu Yan; Zhou Hong-Hao;
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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
mephenytoin; cytochrome P-450 CYP2C19; polymorphism(genetics);

机译：甲妥英细胞色素P-450 CYP2C19;多态性（遗传）;

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1. Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele. [J] . Xiao ZS, Goldstein JA, Xie HG, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 1997,第1期

机译：CYP2C19基因多态性影响中国汉族和白族人群S-表苯妥英表型的发生率差异以及新的罕见CYP2C19突变等位基因的鉴定。
2. Assessing pharmacokinetic differences in Caucasian and East Asian (Japanese, Chinese and Korean) populations driven by CYP2C19 polymorphism using physiologically-based pharmacokinetic modelling [J] . Zhou Li, Sharma Pradeep, Yeo Karen Rowland, European journal of pharmaceutical sciences . 2019,第期

机译：评估通过基于生理学的药代动力学建模的CYP2C19多态性驱动的白种人和东亚（日本，中韩）种群的药代动力学差异
3. Differences in genotype and allele frequency distributions of polymorphic drug metabolizing enzymes CYP2C19 and CYP2D6 in mainland Chinese Mongolian, Hui and Han populations [J] . YinS.-J., NiY.-B., WangS.-M., Journal of Clinical Pharmacy and Therapeutics . 2012,第3期

机译：汉族，回族和汉族人群多态性药物代谢酶CYP2C19和CYP2D6基因型和等位基因频率分布的差异
4. Identifying Individual Differences in Gender, Ethnicity, and Personality from Dialogue for Deception Detection [C] . Sarah Ita Levitan, Yocheved Levitan, Guozhen An, Second workshop on computational approaches to deception detection . 2016

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5. Comparison of polymorphic CYP2D6, CYP2C19 and CYP2A6 in Canadian Native Indian, Caucasian and Chinese populations. [D] . Nowak, Maciej P. 1997

机译：CYP2D6，CYP2C19和CYP2A6多态性在加拿大印第安人，白种人和华裔人群中的比较。
6. Analysis of CYP2C19 Genetic Polymorphism in a Large Ethnic Hakka Population in Southern China [O] . Zhixiong Zhong, Jingyuan Hou, Bing Li, 2017

机译：中国南方大客家人的CYP2C19基因多态性分析

Individual and ethnic differences in CYP2C19 activity in Chinese populations

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