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首页> 外文期刊>Acta Pharmacologica Sinica >Effects of nitroprusside, 3-morpholino-sydnonimine, and spermine on calcium-sensitive potassium currents in gastric antral circular myocytes of guinea pig
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Effects of nitroprusside, 3-morpholino-sydnonimine, and spermine on calcium-sensitive potassium currents in gastric antral circular myocytes of guinea pig

机译:硝普钠,3-吗啉代亚胺和亚精胺对豚鼠胃窦环状肌细胞钙敏感性钾电流的影响

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摘要

Out- ward potassium currents were remarkably inhibited by te- traethylammonium(TEA)1 mmol.L~-1. Charybdotoxin 200 nmol.L~-1, a specific inhibitor of K-Ca channel, also greatly inhibited I_K(Ca). NO donors remakably in- creased I_K(Ca)in guinea pig gastric antral circular my- ocytes with perforated patch-clamp techniques but not conventional whole-cell patch-clamp techniques. NO increases calcium-ac- Tivated potassium, currents in gastric antral circular my- Ocytes of guinea pig, and the effect of NO on I_K(Ca)may Be mediated by cyclic GMP.
机译:四乙基铵(TEA)1 mmol.L〜-1显着抑制了钾的外向电流。 Charybdotoxin 200 nmol.L〜-1,K-Ca通道的特异性抑制剂,也极大地抑制了I_K(Ca)。没有NO供体通过穿孔膜片钳技术显着增加了豚鼠胃窦环形肌细胞中的I_K(Ca),但没有常规的全细胞膜片钳技术。 NO增加了豚鼠胃窦胃圆形肌细胞中钙激活钾的含量,增加了电流,NO对I_K(Ca)的影响可能是由循环GMP介导的。

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