Contribution of genetic variations in estradiol biosynthesis and metabolism enzymes to osteoporosis

Cheng Ze-Neng; Zhou Hong-Hao

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Contribution of genetic variations in estradiol biosynthesis and metabolism enzymes to osteoporosis

机译：雌二醇生物合成和代谢酶的遗传变异对骨质疏松的贡献

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The occurrence of osteoporosis is closely related to serum estradiol level. CYP19 is the most important biosynthesis enzyme and CYP1A2, CYP3A4, and 17beta-HSD are important metabolism enzymes. Any changes in these enzymes activity affects estradiol biosyn- thesis or metabolism, and changes the estradiol serum level. By reviewing the recent literature, it was found that the genetic variations of CYP19, CYP1A2, CYP3A4, and 17beta-HSD are important factors affecting The estradiol serum level, and may be closely related to The development of osteoporosis.

机译：骨质疏松症的发生与血清雌二醇水平密切相关。 CYP19是最重要的生物合成酶，CYP1A2，CYP3A4和17beta-HSD是重要的代谢酶。这些酶活性的任何变化都会影响雌二醇的合成或代谢，并改变雌二醇的血清水平。通过回顾最近的文献，发现CYP19，CYP1A2，CYP3A4和17beta-HSD的遗传变异是影响雌二醇血清水平的重要因素，并且可能与骨质疏松的发展密切相关。

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《Acta Pharmacologica Sinica》 |2000年第7期|p.587-590|共4页
作者
Cheng Ze-Neng; Zhou Hong-Hao;
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正文语种 eng
中图分类药理学;
关键词
estradiol; CYP19; 17beta-HSD;

机译：雌二醇CYP19;17β-HSD;

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1. Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation [J] . ZangerU.M., SchwabM. Pharmacology and Therapeutics: The Journal of the International Encyclopedia of Pharmacology and Therapeutics . 2013,第1期

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2. Ethnic difference in contribution of Sp1 site variation of COLIA1 gene in genetic predisposition to osteoporosis. [J] . Nakajima T, Ota N, Shirai Y, Calcified tissue international. . 1999,第5期

机译：遗传易感性骨质疏松症中COLIA1基因Sp1位点变异的贡献的种族差异。
3. Human variation and CYP enzyme contribution in benfuracarb metabolism in human in vitro hepatic models [J] . AbassK., ReponenP., MattilaS., Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research . 2014,第2期

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4. Metabolism of 17beta-Estradiol in ACI Rat Liver and Mammary Gland After Chronic Estradiol Treatment [C] . Sonia Mesia-Vela, Rosa I Sanchez, Kenneth R. Reuhl, International Symposium on Hormonal Carcinogenesis . 2005

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Contribution of genetic variations in estradiol biosynthesis and metabolism enzymes to osteoporosis

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