Effects of MK-447 on platelet shape change, aggregation, and ATP release by collagen, ADP, and stable analogue of thromboxane A_2 in rabbit platelets

Li Bai-Yan; Zhou Hong; Qiao Guo-Fen

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Effects of MK-447 on platelet shape change, aggregation, and ATP release by collagen, ADP, and stable analogue of thromboxane A_2 in rabbit platelets

机译：MK-447对兔血小板中胶原，ADP和血栓烷A_2稳定类似物的血小板形状变化，聚集和ATP释放的影响

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AIM: To investigate the effects of MK-447 on platelet shape change, aggregation, and ATP release by collagen (Cl), ADP, and stable analogue of thromboxane A_2 (STA_2) in rabbits. METHODS: Platelet shape change and aggregation were quantified in Light transmission by turbidimetric method and release Reaction was assessed by the amount of ATP in platelet- Rich plasma (PRP). CONCLUSION: MK-447 Induced the platelet shape change, and showed the dual Effects, inhibition or enhancement, on the actions by Different aggregating agents.

机译：目的：探讨MK-447对家兔胶原（Cl），ADP和血栓烷A_2（STA_2）稳定类似物对血小板形态变化，聚集和ATP释放的影响。方法：通过比浊法在光透射中定量血小板的形状变化和聚集，并通过富血小板血浆（PRP）中的ATP含量评估释放反应。结论：MK-447诱导血小板形态变化，并表现出对不同聚集剂作用的双重抑制或增强作用。

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《Acta Pharmacologica Sinica》 |1999年第7期|p.627-630|共4页
作者
Li Bai-Yan; Zhou Hong; Qiao Guo-Fen;
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正文语种 eng
中图分类药理学;
关键词
MK-447; collagen; adenosine diphosphate;

机译：MK-447;胶原;二磷酸腺苷;

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2. Effects of 5-HT released from platelet on thrombin-induced aggregation and ATP release in rabbit platelets in vitro [J] . Li Bai-Yan, Li Wen-Han Acta Pharmacologica Sinica . 1998,第4期

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3. Differential effects of adenine nucleotide analogues on shape change and aggregation induced by adenosine 5'-diphosphate (ADP) in human platelets [J] . Hye-Seong Park, Susanna M. O. Hourani British Journal of Pharmacology . 1999,第6期

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4. Transfusion with synthetic platelet substitutes, H12-(ADP)liposomes, effectively rescues thrombocytopenic rabbits from massive hemorrhage [C] . Masato Takikawa, Kosuke Hagisawa, Manabu Kinoshita, World biomaterials congress . 2016

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5. Localized release of platelet-derived growth factor (PDGF) in the development of a collagen based tissue repair and regeneration model [D] . Tsao, Christopher 2013

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6. Differential effects of adenine nucleotide analogues on shape change and aggregation induced by adenosine 5′-diphosphate (ADP) in human platelets [O] . Hye-Seong Park, Susanna M O Hourani 1999

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7. Differential effects of adenine nucleotide analogues on shape change and aggregation induced by adenosine 5 '-diphospbate (ADP) in human platelets [O] . Park, HS, Hourani, SMO 1999

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8. Free Platelet Count and Size Distribution During C1q Inhibition of Collagen-Induced Platelet Aggregation [R] . Csako, G., Suba, E. A. 1987

机译：C1q抑制胶原诱导的血小板聚集过程中游离血小板计数和大小分布

Effects of MK-447 on platelet shape change, aggregation, and ATP release by collagen, ADP, and stable analogue of thromboxane A_2 in rabbit platelets

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