L-Pyroglutamic acid protects rat cortical neurons against sodium glutamate-induced injury

Xiao Xiao-Qiu; Liu Guo-Qing

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L-Pyroglutamic acid protects rat cortical neurons against sodium glutamate-induced injury

机译：L-焦谷氨酸保护大鼠皮质神经元免受谷氨酸钠诱导的损伤

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AIM: To evaluate the effects of L-pyroglutamic acid (L-PGA, L-5-oxo-2-pyrrolidinecaroxylic acid) on sodium glutamate-induced neurotoxicity in rat cortical neurons. METHODS: In primary cortical cultures from 16-d-old fetal rat, neuronal viability and contents of nitrite in the bathing medium after transient exposure to sodium glutamate (Glu) were measured; with Fura 2-AM as an intracellular calcium indicator, AR-CM- MIC cation measurement system was used to examine Cytosolic free calcium ([Ca~2+]_i).

机译：目的：评估L-焦谷氨酸（L-PGA，L-5-氧-2-吡咯烷丙酸）对谷氨酸钠诱导的大鼠皮层神经元神经毒性的影响。方法：在16日龄胎鼠的原代皮层培养物中，测量了谷氨酸钠（Glu）的瞬时暴露后，沐浴液中神经元的活力和亚硝酸盐的含量。以Fura 2-AM为细胞内钙指示剂，使用AR-CM-MIC阳离子测量系统检查胞质游离钙（[Ca〜2 +] _ i）。

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《Acta Pharmacologica Sinica》 |1999年第8期|p.733-736|共4页
作者
Xiao Xiao-Qiu; Liu Guo-Qing;
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正文语种 eng
中图分类药理学;
关键词
pyrrolidonecarboxylid acid; sodium glutamate; calcium;

机译：吡咯烷酮羧酸盐;谷氨酸钠钙;

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L-Pyroglutamic acid protects rat cortical neurons against sodium glutamate-induced injury

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