Bepridil inhibition of sodium current in rat hippocampal CA1 neurons

Hu Hui-Juan; Yang Dong-Mei; Dai De-Zai

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Bepridil inhibition of sodium current in rat hippocampal CA1 neurons

机译：贝普地尔抑制大鼠海马CA1神经元钠电流

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AIM: To study the effects of bepridil on sodium current in rat hippocampal neurons. METHODS: All experiments were performed on acutely isolated hippocampal pyramidal neurons by means of whole-cell patch-clamp techniques. Recording media contained ion channel blockers to allow the selective activation of voltage-dependent sodium current. CONCLUSION: Bepridil blocked voltage-dependent Sodium current of hippocampal Cal neurons and might Have therapeutic actions for ischemia-induced brain Damage.

机译：目的：研究贝普利尔对大鼠海马神经元钠电流的影响。方法：所有实验均通过全细胞膜片钳技术在急性分离的海马锥体神经元上进行。记录介质包含离子通道阻滞剂，以允许选择性激活电压依赖性钠电流。结论：Bepridil阻断了海马Cal神经元的电压依赖性钠电流，可能对缺血性脑损伤具有治疗作用。

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《Acta Pharmacologica Sinica》 |1999年第9期|p.819-823|共5页
作者
Hu Hui-Juan; Yang Dong-Mei; Dai De-Zai;
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正文语种 eng
中图分类药理学;
关键词
hippocampus; patch-clamp techniques; bepridil;

机译：海马膜片钳技术;贝普地尔;

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1. Inhibition of oxidative metabolism increases persistent sodium current in rat CA1 hippocampal neurons. [J] . Hammarstrom AK, nu.edu.au, Gage PW The Journal of Physiology . 1998,第Pta3期

机译：氧化代谢的抑制作用增加大鼠CA1海马神经元的持续钠电流。
2. The rostral migratory stream generates hippocampal CA1 pyramidal-like neurons in a novel organotypic slice co-culture model The rostral migratory stream generates hippocampal CA1 pyramidal-like neurons in a novel organotypic slice co-culture model The rostral migratory stream generates hippocampal CA1 pyramidal-like neurons in a novel organotypic slice co-culture model [J] . Michael Frotscher, Rolf Knoth, Imre Vida, Biology Open . 2015,第10期

机译：在一种新的器官型切片共培养模型中，鼻部迁移流产生海马CA1锥体样神经元。新型器官型切片共培养模型中的神经元
3. Enhancement of sodium metabisulfite on sodium currents in acutely isolated rat hippocampal CA1 neurons [J] . Ziqiang Meng, Aifang Nie Environmental toxicology and pharmacology . 2005,第1期

机译：偏亚硫酸氢钠对急性分离的大鼠海马CA1神经元钠电流的增强作用
4. Current Source Density Analysis as a Tool to Constrain the Parameter Space in Hippocampal CA1 Neuron Models [C] . Pablo Varona, Jose Manuel Ibarz, Juan Alberto Sigueenza, Biological and artificial computation : From neurosciene to technology . 1997

机译：电流源密度分析作为约束海马CA1神经元模型参数空间的工具
5. Intrinsic plasticity in CA1 pyramidal neurons: Role of calcium(2+)- and sodium(+)-activated potassium currents in aging and Alzheimer's disease. [D] . Kaczorowski, Catherine Cook. 2006

机译：CA1锥体神经元的内在可塑性：钙（2+）和钠（+）激活的钾电流在衰老和阿尔茨海默氏病中的作用。
6. Inhibition of oxidative metabolism increases persistent sodium current in rat CA1 hippocampal neurons [O] . A K M Hammarström, P W Gage 1998

机译：氧化代谢的抑制作用增加大鼠CA1海马神经元的持续钠电流
7. Inhibition of oxidative metabolism increases persistent sodium current in rat CA1 hippocampal neurons [O] . Hammarström, A K M, Gage, P W 1998

机译：氧化代谢的抑制作用增加大鼠CA1海马神经元的持续钠电流

Bepridil inhibition of sodium current in rat hippocampal CA1 neurons

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