Pharmacokinetics of flutamide and its metabolite 2-hydroxyflutamide in normal and hepatic injury rats

Xu Chang-Jiang; Li Duan

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Pharmacokinetics of flutamide and its metabolite 2-hydroxyflutamide in normal and hepatic injury rats

机译：氟他胺及其代谢产物2-羟基氟他胺在正常和肝损伤大鼠中的药代动力学

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Conclusion: This HPLC assay was sensitive and precise, and the elimination of Flu and HF was inhibited significantly due to hepatic Injury. Aim: To develop a new HPLC assay to study the Pharmacokinetics of flutamide(Flu)and its active Metabolite 2-hydoxyflutamide(HF)in rats. Methods: Normal or hepatic injury rats were given Ig Flu 50 mg.kg~-1. Reverse phase HPLC was Developed with aμ-Bondapak C 18 column. Internal Standard was methyltestosterone. The mobile phase Was a mixture of methonal: acetonitrile: water: diethyl Ether=40:20:35:1(vol).

机译：结论：该HPLC方法灵敏，准确，并且由于肝损伤而明显抑制了Flu和HF的消除。目的：建立新的高效液相色谱法研究氟他胺（Flu）及其活性代谢物2-羟氟他胺（HF）的药代动力学。方法：正常或肝损伤大鼠给予Ig Flu 50 mg.kg〜-1。用μ-BondapakC 18色谱柱开发了反相HPLC。内标为甲基睾丸激素。流动相是甲腈：乙腈：水：二乙醚＝ 40∶20∶35∶1（体积）的混合物。

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《Acta Pharmacologica Sinica》 |1998年第1期|p.39-43|共5页
作者
Xu Chang-Jiang; Li Duan;
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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
flutamide; 2-hydroxyflutamide; pharmacokinetics; liver;

机译：氟他胺;2-羟基氟他胺;药代动力学肝;

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2. Integral pharmacokinetics of multiple lignan components in normal, CCl4-induced hepatic injury and hepatoprotective agents pretreated rats and correlations with hepatic injury biomarkers. [J] . Xie Y, Hao H, Kang A, Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2010,第2期

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3. Flutamide-induced hepatic dysfunction in relation to steady-state plasma concentrations of flutamide and its metabolites [J] . Yoshio Aizawa, Isao Ikemoto, Koichi Kishimoto, Molecular and Cellular Biochemistry: An International Journal for Chemical Biology . 2003,第1a2期

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Pharmacokinetics of flutamide and its metabolite 2-hydroxyflutamide in normal and hepatic injury rats

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