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首页> 外文期刊>Acta Pharmacologica Sinica >Preproopiomelanocortin and preprodynorphin mRNA expression in rat brain after electroacupuncture + droperidol
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Preproopiomelanocortin and preprodynorphin mRNA expression in rat brain after electroacupuncture + droperidol

机译：电针+氟哌利多后大鼠脑内前皮质前黑皮质激素和前炔诺啡mRNA的表达。

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AIM: To study the expression of prepro- opiomelanocortin (POMC) and preprodynorphin (PPD) mRNA following the combination of electroacupuncture (FA) with droperidol (Dro), a dopamine receptor antagonist. METHODS: The brains and spinal cords of Sprague-Dawley rats were sectioned after combination of EA with Dro, and the gene expression was investigated using nonradioactive in situ hybridization histochemistry (ISHH). RESULTS: Ten hours after EA, the POMC mRNA expression was enhanced; the expression was further enhanced when EA was combined with Dro. The expression of PPD mRNA showed regional difference in central nervous system (CNS): in spinal cord, EA enhanced the PPD mRNA expression and the combination of EA with Dro further promoted the expression; in the brain, the PPD mRNA expression after EA or combination of EA with Dm showed no obvious change in most regions (caudate-putamen, accumbens, arcuate nucleus of hypothalamus) or was decreased in supraoptic nucleus.
机译：目的：研究电针（FA）与多巴胺受体拮抗剂氟哌利多（Dro）结合后，前原黑皮皮质激素（POMC）和前强啡肽（PPD）mRNA的表达。方法：将EA与Dro混合后，对Sprague-Dawley大鼠的大脑和脊髓进行切片，并使用非放射性原位杂交组织化学（ISHH）研究其基因表达。结果：EA后10小时，POMC mRNA表达增强。当EA与Dro结合使用时，表达进一步增强。 PPD mRNA的表达在中枢神经系统（CNS）中存在区域差异：EA在脊髓中增强了PPD mRNA的表达，EA与Dro的结合进一步促进了PPD mRNA的表达。在大脑中，EA或EA与Dm联合使用后，PPD mRNA的表达在大多数区域（尾状丘脑，伏伏，下丘脑弓状核）无明显变化，或在视上核降低。

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