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首页> 外文期刊>Advanced Functional Materials >Photothermal-Controlled Nanotubes with Surface Charge Flipping Ability for Precise Synergistic Therapy of Triple-Negative Breast Cancer
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Photothermal-Controlled Nanotubes with Surface Charge Flipping Ability for Precise Synergistic Therapy of Triple-Negative Breast Cancer

机译：具有表面电荷翻转能力的光热控制纳米管用于三阴性乳腺癌的精确协同治疗。

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Owing to the highly malignant and invasive innate character of triple-negative breast cancers (TNBCs), it is easy to relapse after chemotherapy; thus, there are still no effective and specific targeted therapies. In this study, a carbon nanotube (CNT)-based nanosystem Se@CNTs with surface charge flipping and targeted ability is rationally designed and successfully synthesized for precise chemo-photothermal synergistic therapy of TNBCs. The acid-labile beta-carboxylic acid group is used to reversibly functionalize the amine groups, thus forming charge-reversal nanoparticles to enhance the bioresponsive cellular uptake. The internalized Se@CNTs combined with laser irradiation induces reactive oxygen species (ROS) overproduction, which activates apoptosis-related proteins to trigger cancer cell apoptosis synergistically. Meanwhile, Se@CNTs also suppresses the invasion and migration of TNBC cells by regulating the related signaling pathways. Importantly, in combination with laser irradiation, Se@CNTs effectively inhibits the tumor growth, as demonstrated by the high tumor ablation activity in vivo through chemo-phototherapy, but shows no significant histological change in the main organs. Taken together, this study provides a strategy for rational design of next-generation nanomedicines for precise chemo-photothermal synergistic therapy of malignant TNBCs.
机译：由于三阴性乳腺癌（TNBCs）具有高度恶性和浸润性，因此化疗后很容易复发。因此，仍然没有有效且具体的靶向疗法。在这项研究中，合理设计并成功合成了具有表面电荷翻转和靶向能力的基于碳纳米管（CNT）的纳米系统Se @ CNTs，用于TNBCs的精确化学-光热协同治疗。酸不稳定的β-羧酸基团用于可逆地官能化胺基团，从而形成电荷反转纳米颗粒以增强生物反应性细胞摄取。内在化的Se @ CNTs与激光照射相结合会诱导活性氧（ROS）过度产生，从而激活凋亡相关蛋白，从而协同触发癌细胞凋亡。同时，Se @ CNTs还通过调节相关的信号通路来抑制TNBC细胞的侵袭和迁移。重要的是，结合激光照射，Se @ CNTs有效地抑制了肿瘤的生长，这通过化学光疗法在体内具有很高的肿瘤消融活性得到证明，但在主要器官中并未显示出明显的组织学变化。综上所述，本研究为合理设计用于恶性TNBC的化学-光热协同治疗的下一代纳米药物提供了策略。

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