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首页> 外文期刊>Advanced Functional Materials >Supramolecular Antifouling Additives for Robust and Efficient Functionalization of Elastomeric Materials: Molecular Design Matters
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Supramolecular Antifouling Additives for Robust and Efficient Functionalization of Elastomeric Materials: Molecular Design Matters

机译：超强防污添加剂，用于弹性体材料的稳固和高效功能化：分子设计问题

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摘要

The ultimate functionality of elastomeric materials can be largely influenced by the molecular design of antifouling additives that interact through directed hydrogen bonding bisurea motifs. Herein, three additives, composed of matching bisurea groups and antifouling oligo(ethylene glycol) (OEG) functionalities, are judiciously designed. The first additive is composed of one bisurea and one OEG, the second additive of one bisurea and two OEGs, and the third additive of two bisurea and one OEG. On solution-cast films, non-cell adhesive properties are dependent on the amount of incorporated OEG irrespective of the bisurea design; however, on 3D electrospun scaffolds only the additive that consists of two bisurea moieties connected via an OEG functionality ensures proper non-cell adhesive properties. Interestingly, robust non-cell adhesive properties are maintained, both with repeated cell seeding and after partial enzymatic degradation of the scaffold. These results highlight the importance of additive design in supramolecular functionalization and show that translation from simple 2D solution-cast films to 3D electrospun scaffolds is not trivial with respect to additive presentation and functionality.
机译：弹性材料的最终功能在很大程度上受到防污添加剂的分子设计的影响，这些防污添加剂通过定向氢键结合的双surea图案相互作用。在此，明智地设计了由匹配的双surea基团和防污低聚乙二醇（OEG）功能组成的三种添加剂。第一添加剂由一个双担保和一个OEG组成，第二添加剂由一个担保和两个OEG组成，第三添加剂由两个担保和一个OEG组成。在溶液流延薄膜上，无细胞粘合剂的性能取决于掺入的OEG的量，而与Bisurea设计无关。但是，在3D电纺脚手架上，只有由两个通过OEG功能连接的Bisurea部分组成的添加剂才能确保适当的非细胞粘合特性。有趣的是，通过反复的细胞接种和支架的部分酶降解后，都保持了稳固的非细胞粘附性能。这些结果凸显了添加剂设计在超分子功能化中的重要性，并表明从简单的2D溶液浇铸膜到3D电纺丝支架的翻译对于添加剂的呈现和功能而言并非微不足道。

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  • 来源
    《Advanced Functional Materials》 |2019年第1期|1805375.1-1805375.11|共11页
  • 作者

    Ippel Bastiaan D.; Keizer Henk M.; Dankers Patricia Y. W.;

  • 作者单位

    Eindhoven Univ Technol, Inst Complex Mol Syst, POB 513, NL-5600 MB Eindhoven, Netherlands|Eindhoven Univ Technol, Lab Cell & Tissue Engn, POB 513, NL-5600 MB Eindhoven, Netherlands;

    SyMO Chem BV, Den Dolech 2, NL-5612 AZ Eindhoven, Netherlands;

    Eindhoven Univ Technol, Inst Complex Mol Syst, POB 513, NL-5600 MB Eindhoven, Netherlands|Eindhoven Univ Technol, Lab Cell & Tissue Engn, POB 513, NL-5600 MB Eindhoven, Netherlands|Eindhoven Univ Technol, Biol Chem Lab, POB 513, NL-5600 MB Eindhoven, Netherlands;

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  • 正文语种 eng
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  • 关键词

    additives; antifouling; molecular design; supramolecular biomaterials;

    机译：添加剂;防污;分子设计;超分子生物材料;

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