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首页> 外文期刊>Advanced Functional Materials >Multivalent Glycosheets for Double Light-Driven Therapy of Multidrug-Resistant Bacteria on Wounds
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Multivalent Glycosheets for Double Light-Driven Therapy of Multidrug-Resistant Bacteria on Wounds

机译：多价糖片用于伤口上的多药耐药细菌的双重光驱动疗法

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摘要

With the evergrowing threat posed by multidrug resistance of bacteria, the development of effective antibacterial agents remains a global challenge. Infection with multidrug-resistant bacteria in hospitals significantly impairs the healing of wounds caused by deep-burn injuries or diabetic foot ulceration, leading to a high mortality rate among these patients. A multivalent glycosheet for the double light-driven therapy against multidrug-resistant Pseudomonas aeruginosa (P. aeruginosa) infection on wounds is developed here. Galactose- and fucose-based ligands are self-assembled to form a glyco-layer on the surface of thin-layer molybdenum disulfide, producing the glycosheets capable of selectively localizing P. aeruginosa through multivalent carbohydrate-lectin interactions. The glycosheets loaded with antibiotics have proven applicable for: 1) near-infrared-light driven, in situ thermal release of antibiotics, increasing bacterial membrane permeability, and 2) white light-driven reactive-oxygen-species production to more thoroughly kill the bacteria. The targetability, together with the light sensibility, of the glycosheets enables a highly effective and optically controlled therapeutic regime for the healing of wounds infected by multidrug-resistant as well as clinically isolated P. aeruginosa.
机译：随着细菌对多药耐药性的日益增长的威胁，有效的抗菌剂的开发仍然是全球性的挑战。医院中多药耐药细菌的感染严重损害了深烧伤或糖尿病足溃疡引起的伤口愈合，导致这些患者的高死亡率。在这里开发了一种用于双光驱动疗法的多价糖片，用于对抗伤口上的多重耐药铜绿假单胞菌（P. aeruginosa）感染。基于半乳糖和岩藻糖的配体是自组装的，在薄层二硫化钼的表面上形成糖层，从而产生能够通过多价碳水化合物-凝集素相互作用选择性定位铜绿假单胞菌的糖片。载有抗生素的糖片被证明适用于：1）近红外光驱动的抗生素原位热释放，增加细菌膜的通透性，以及2）白光驱动的活性氧物种的产生，以更彻底地杀死细菌。 。糖片的可靶向性以及光敏性使得能够高效且光学控制的治疗方案用于治愈被多重耐药性和临床分离的铜绿假单胞菌感染的伤口。

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  • 来源
    《Advanced Functional Materials》 |2019年第14期|1806986.1-1806986.10|共10页
  • 作者

    Hu Xi-Le; Chu Linyang; Dong Xiaojing; Chen Cuo-Rong; Tang Tingting; Chen Daijie; He Xiao-Peng; Tian He;

  • 作者单位

    East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat, 130 Meilong RD, Shanghai 200237, Peoples R China|East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Int Res Lab Precis Chem & Mol Engn, 130 Meilong RD, Shanghai 200237, Peoples R China;

    Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Orthoped Surg,Shanghai Key Lab Orthoped Impl, Shanghai 200011, Peoples R China;

    China State Inst Pharmaceut Ind, Shanghai Inst Pharmaceut Ind, State Key Lab New Drug & Pharmaceut Proc, Shanghai 200040, Peoples R China;

    East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat, 130 Meilong RD, Shanghai 200237, Peoples R China|East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Int Res Lab Precis Chem & Mol Engn, 130 Meilong RD, Shanghai 200237, Peoples R China;

    Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Orthoped Surg,Shanghai Key Lab Orthoped Impl, Shanghai 200011, Peoples R China;

    China State Inst Pharmaceut Ind, Shanghai Inst Pharmaceut Ind, State Key Lab New Drug & Pharmaceut Proc, Shanghai 200040, Peoples R China|Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan RD, Shanghai 200240, Peoples R China;

    East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat, 130 Meilong RD, Shanghai 200237, Peoples R China|East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Int Res Lab Precis Chem & Mol Engn, 130 Meilong RD, Shanghai 200237, Peoples R China;

    East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat, 130 Meilong RD, Shanghai 200237, Peoples R China|East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Int Res Lab Precis Chem & Mol Engn, 130 Meilong RD, Shanghai 200237, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    light-driven; multidrug-resistant bacteria; multivalent; thin-layer material; wounds;

    机译：光驱动;耐多药细菌;多价;薄层材料;伤口;

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