Thickness and Sphericity Control of Hollow Hard Silica Shells through Iron (Ⅲ) Doping: Low Threshold Ultrasound Contrast Agents

Huang Ching-Hsin; Wang James; Yang Jian; Oviedo Juan Pablo; Na Seungjin M.; Trogler William C.; Blair Sarah L.; Kim Moon J.; Kummel Andrew C.

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Thickness and Sphericity Control of Hollow Hard Silica Shells through Iron (Ⅲ) Doping: Low Threshold Ultrasound Contrast Agents

机译：铁（Ⅲ）掺杂对空心硬质硅壳的厚度和球度的控制：低阈值超声造影剂

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Silica particles are convenient ultrasound imaging contrast agents because of their long imaging time and ease of modification; however, they require a relatively high insonation power for imaging and have low biodegradability. In this study, 2 mu m ultrathin asymmetric hollow silica particles doped with iron (III) (Fe(III)-SiO2) are synthesized to produce biodegradable hard shelled particles with a low acoustic power threshold comparable with commercial soft microbubble contrast agents (Definity) yet with much longer in vivo ultrasound imaging time. Furthermore, high intensity focused ultrasound ablation enhancement with these particles shows a 2.5-fold higher temperature elevation than with Definity at the same applied power. The low power visualization improves utilization of the silica shells as an adjuvant in localized immunotherapy. The data are consistent with asymmetric engineering of hard particle properties that improve functionality of hard versus soft particles.

机译：二氧化硅颗粒具有很长的成像时间并且易于修饰，因此是方便的超声成像造影剂。但是，它们需要较高的声波成像能力，并且生物降解性低。在这项研究中，合成了2微米的掺有铁（III）（Fe（III）-SiO2）的超薄不对称中空二氧化硅颗粒，可生产出可生物降解的硬壳颗粒，其声功率阈值可与市售的软微泡造影剂（Definity）媲美但体内超声成像时间更长。此外，在相同的施加功率下，用这些颗粒进行的高强度聚焦超声消融增强显示出比Definity高2.5倍的温度升高。低功率可视化可提高二氧化硅壳作为局部免疫治疗佐剂的利用率。数据与硬颗粒特性的不对称工程相一致，硬颗粒特性的非对称工程可改善硬颗粒与软颗粒的功能。

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《Advanced Functional Materials》 |2019年第33期|1900893.1-1900893.9|共9页
作者
Huang Ching-Hsin; Wang James; Yang Jian; Oviedo Juan Pablo; Na Seungjin M.; Trogler William C.; Blair Sarah L.; Kim Moon J.; Kummel Andrew C.;
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作者单位

Univ Calif San Diego, Dept Chem & Biochem, 9500 Gilman Dr, La Jolla, CA 92093 USA;

Univ Calif San Diego, Dept Chem & Biochem, 9500 Gilman Dr, La Jolla, CA 92093 USA;

Univ Calif San Diego, Dept Chem & Biochem, 9500 Gilman Dr, La Jolla, CA 92093 USA;

Univ Texas Dallas, Dept Mat Sci & Engn, 800 W Campbell Rd, Richardson, TX 75080 USA;

Univ Texas Dallas, Dept Mat Sci & Engn, 800 W Campbell Rd, Richardson, TX 75080 USA;

Univ Calif San Diego, Dept Chem & Biochem, 9500 Gilman Dr, La Jolla, CA 92093 USA;

Moores Canc Ctr, 3855 Hlth Sci Dr, La Jolla, CA 92093 USA;

Univ Texas Dallas, Dept Mat Sci & Engn, 800 W Campbell Rd, Richardson, TX 75080 USA;

Univ Calif San Diego, Dept Chem & Biochem, 9500 Gilman Dr, La Jolla, CA 92093 USA;

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正文语种 eng
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关键词
asymmetry; hard shells; iron; silica; ultrasound contrast agents;

机译：不对称;硬壳;铁;二氧化硅;超声造影剂;

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1. Hollow spherical nanoparticulate aggregates as potential ultrasound contrast agent: shell thickness characterization. [J] . Hadinoto K, Cheow WS Drug development and industrial pharmacy . 2009,第10期

机译：中空球形纳米颗粒聚集体作为潜在的超声造影剂：壳厚度表征。
2. Mechanically Tunable Hollow Silica Ultrathin Nanoshells for Ultrasound Contrast Agents [J] . Liberman A., Wang James, Lu N., Advanced Functional Materials . 2015,第26期

机译：用于超声造影剂的机械可调中空二氧化硅超薄纳米壳
3. Integrated processing of contrast pulse sequencing ultrasound imaging for enhanced active contrast of hollow gas filled silica nanoshells and microshells [J] . Casey N. Ta, Alexander Liberman, H. Paul Martinez, Journal of Vacuum Science & Technology . 2012,第2期

机译：对比脉冲测序超声成像的集成处理，可增强中空充气二氧化硅纳米壳和微壳的主动对比
4. Influence of shell-thickness-to-radius ratio on buckling and rupture of polymer-shelled ultrasound contrast agents [C] . Sujeethraj Koppolu, Parag V. Chitnis, Jonathan Mamou, IEEE International Ultrasonics Symposium . 2012

机译：壳体厚度与半径比对聚合物壳超声造影剂屈曲和破裂的影响
5. Development of Silica Hollow Shells for Ultrasound Imaging and Cancer Immunotherapy [D] . Huang, Ching-Hsin. 2021

机译：二氧化硅空心壳的开发用于超声成像和癌症免疫疗法
6. Mechanically Tunable Hollow Silica Ultrathin Nanoshells for Ultrasound Contrast Agents [O] . A. Liberman, J. Wang, Dr. N. Lu, -1

机译：用于超声造影剂的机械可调中空二氧化硅超薄纳米壳
7. Thickness and Sphericity Control of Hollow Hard Silica Shells through Iron (III) Doping: Low Threshold Ultrasound Contrast Agents [O] . Ching‐Hsin Huang, James Wang, Jian Yang, 2019

机译：中空硬二氧化硅壳通过铁（III）掺杂的厚度和球形控制：低阈值超声造影剂

Thickness and Sphericity Control of Hollow Hard Silica Shells through Iron (Ⅲ) Doping: Low Threshold Ultrasound Contrast Agents

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