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首页> 外文期刊>Advanced Functional Materials >Human Platelet Membrane Functionalized Microchips with Plasmonic Codes for Cancer Detection
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Human Platelet Membrane Functionalized Microchips with Plasmonic Codes for Cancer Detection

机译：人血浆膜功能化芯片的等离子代码检测癌症。

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摘要

The possibility of functional roles played by platelets in close alliance with cancer cells has inspired the design of new biomimetic systems that exploit platelet cancer cell interactions. Here, the role of platelets in cancer diagnostics is leveraged to design a microfluidic platform capable of detecting cancer-derived extracellular vesicles (EVs) from ultrasmall volumes (1 mu L) of human plasma samples. Further, the captured EVs are counted by direct optical coding of plasmonic nanoprobes modified with EV-specific antibodies. Owing to the inherent properties of platelets for multifaceted interaction with cancer cells, the microfluidic chip equipped with a biologically interfaced platelet membrane-cloaked surface (denoted "PLT-Chip") can capture a significantly higher number of EVs from multiple types of cancer cell lines (prostate, lung, bladder, and breast) than the normal cell-derived EVs. Furthermore, this chip allows the monitoring of the growth of tumor spheroids (100 mu m-2.5 mm) and clearly distinguishes the plasma of cancer patients from that of normal healthy controls. This robust, multifaceted, and cancer-specific binding affinity, coupled with excellent biocompatibility, is a unique feature of platelet membrane-cloaked surfaces, which therefore represent promising alternatives to antibodies for application in EVs-based cancer theranostics.
机译：血小板与癌细胞紧密结合所发挥的功能性作用的可能性激发了利用血小板癌细胞相互作用的新型仿生系统的设计。在这里，利用血小板在癌症诊断中的作用来设计一种微流体平台，该平台能够从超小体积（1微升）的人血浆样本中检测出癌症来源的细胞外囊泡（EV）。此外，通过用EV特异性抗体修饰的等离子体纳米探针的直接光学编码来计数捕获的EV。由于血小板具有与癌细胞多方面相互作用的固有特性，配备生物界面血小板膜隐身表面的微流控芯片（称为“ PLT-Chip”）可以捕获来自多种癌症的大量电动汽车。细胞系（前列腺，肺，膀胱和乳腺）比正常细胞衍生的电动车。此外，该芯片可以监测肿瘤球体的生长情况（100微米至2.5毫米），并且可以清楚地区分癌症患者的血浆与正常健康人的血浆。这种强大的，多方面的和癌症特异性的结合亲和力，以及出色的生物相容性，是血小板膜掩盖表面的独特功能，因此代表了可用于基于EVs的癌症治疗方法的抗体的有希望的替代品。

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  • 来源
    《Advanced Functional Materials》 |2019年第30期|1902669.1-1902669.7|共7页
  • 作者

    Kumar Sumit; Han Jae-A; Michael Issac J.; Ki Dongyeob; Sunkara Vijaya; Park Juhee; Gautam Shreedhar; Ha Hong Koo; Zhang Liangfang; Cho Yoon-Kyoung;

  • 作者单位

    IBS, Ctr Soft & Living Matter, Ulsan 44919, South Korea;

    IBS, Ctr Soft & Living Matter, Ulsan 44919, South Korea|UNIST, Sch Life Sci, Dept Biomed Engn, Ulsan 44919, South Korea;

    IBS, Ctr Soft & Living Matter, Ulsan 44919, South Korea|UNIST, Sch Life Sci, Dept Biomed Engn, Ulsan 44919, South Korea;

    UNIST, Sch Life Sci, Dept Biomed Engn, Ulsan 44919, South Korea;

    IBS, Ctr Soft & Living Matter, Ulsan 44919, South Korea;

    IBS, Ctr Soft & Living Matter, Ulsan 44919, South Korea;

    IBS, Ctr Soft & Living Matter, Ulsan 44919, South Korea;

    Pusan Natl Univ, Pusan Natl Univ Hosp, Sch Med, Dept Urol, Busan 49241, South Korea;

    Univ Calif San Diego, Dept Nanoengn, La Jolla, CA 92093 USA;

    IBS, Ctr Soft & Living Matter, Ulsan 44919, South Korea|UNIST, Sch Life Sci, Dept Biomed Engn, Ulsan 44919, South Korea;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    cancer; extracellular vesicles; plasmonic coupling; platelets;

    机译：癌症;细胞外囊;等离子体耦合;血小板;

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