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首页> 外文期刊>Advanced Functional Materials >Designing Bioinspired 2D MoSe_2 Nanosheet for Efficient Photothermal-Triggered Cancer Immunotherapy with Reprogramming Tumor-Associated Macrophages
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Designing Bioinspired 2D MoSe_2 Nanosheet for Efficient Photothermal-Triggered Cancer Immunotherapy with Reprogramming Tumor-Associated Macrophages

机译：设计具有生物启发性的二维MoSe_2纳米片，用于通过与肿瘤相关的巨噬细胞重编程来进行有效的光热触发的癌症免疫治疗。

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摘要

Nonspecific absorption and clearance of nanomaterials during circulation is the major cause for treatment failure in nanomedicine-based cancer therapy. Therefore, herein bioinspired red blood cell (RBC) membrane is employed to camouflage 2D MoSe2 nanosheets with high photothermal conversion efficiency to achieve enhanced hemocompatibility and circulation time by preventing macrophage phagocytosis. RBC MoSe2-potentiated photothermal therapy (PTT) demonstrates potent in vivo antitumor efficacy, which triggers the release of tumor-associated antigens to activate cytotoxic T lymphocytes and inactivate the PD-1/PD-L1 pathway to avoid immunologic escape. Furthermore, in the ablated tumor microenvironment, the tumor-associated macrophages are effectively reprogrammed to tumoricidal M1 phenotype to potentiate the antitumor action. Taken together, this biomimetic functionalization thus provides a substantial advance in personalized PTT-triggered immunotherapy for clinical translation.
机译：纳米材料在循环过程中的非特异性吸收和清除是基于纳米药物的癌症治疗失败的主要原因。因此，本文采用生物启发的红细胞（RBC）膜来伪装具有高光热转换效率的二维MoSe2纳米片，以通过防止巨噬细胞吞噬作用来实现增强的血液相容性和循环时间。 RBC MoSe2增强的光热疗法（PTT）表现出强大的体内抗肿瘤功效，可触发肿瘤相关抗原的释放来激活细胞毒性T淋巴细胞并灭活PD-1 / PD-L1通路，从而避免免疫逃逸。此外，在消融的肿瘤微环境中，将肿瘤相关的巨噬细胞有效地重编程为具有杀伤性的M1表型，以增强抗肿瘤作用。总体而言，这种仿生功能化为个性化PTT触发的免疫治疗提供了重大进展，可用于临床翻译。

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  • 来源
    《Advanced Functional Materials》 |2019年第30期|1901240.1-1901240.15|共15页
  • 作者

    He Lizhen; Nie Tianqi; Xia Xiaojun; Liu Ting; Huang Yanyu; Wang Xiaojuan; Chen Tionfeng;

  • 作者单位

    Wenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Wenzhou 325000, Peoples R China|Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Peoples R China|Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China;

    Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China;

    Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China;

    Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China;

    Wenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Wenzhou 325000, Peoples R China|Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Peoples R China|Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    2D materials; cancer immunotherapy; photothermal therapy; reprogramming; tumor-associated macrophages;

    机译：2D材料;癌症免疫疗法;光热疗法;重编程;肿瘤相关的巨噬细胞;

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