• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Functional Materials >A Dual-Functional Photosensitizer for Ultraefficient Photodynamic Therapy and Synchronous Anticancer Efficacy Monitoring
【24h】

A Dual-Functional Photosensitizer for Ultraefficient Photodynamic Therapy and Synchronous Anticancer Efficacy Monitoring

机译：用于高效光动力疗法和同步抗癌疗效监测的双功能光敏剂

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A dual-functional photosensitizer that demonstrates exceptional photodynamic therapy (PDT) efficacy while simultaneously self-monitoring the therapeutic response in real time is reported here. Possessing an ultrahigh O-1(2) quantum yield of 98.6% in water, the photosensitizer TPCI can efficiently induce cell death in a series of carcinoma cells (IC50 values less than 300 x 10(-9) m) upon irradiation with an extremely low fluence (460 nm, 4 mW cm(-2) for 10 min). In addition, TPCI can self-monitor cell death in real time. It is weakly fluorescent in living cells before irradiation and lights up the nuclei concomitantly with cell death during PDT treatment by binding with chromatin to activate its aggregation-induced emission, attributed to its strong binding affinity with DNA. In vivo studies using mouse models bearing H22 and B16F10 tumor cells validate the ultraefficient PDT efficacy of TPCI as well as the precise real-time noninvasive readout of the tumor response from the beginning of cancer treatment. The dual-functional TPCI serves as an excellent candidate for single-agent photodynamic theranostics, and this work represents a new paradigm for the development of molecules with multiple intrinsic functions for future self-reporting medical applications.
机译：本文报道了一种双功能光敏剂，该光敏剂具有出色的光动力疗法（PDT）功效，同时可以实时自我监测治疗反应。在水中，光敏剂TPCI在水中具有98.6％的超高O-1（2）量子产率，可在一系列癌细胞（IC50值小于300 x 10（-9）m）的情况下有效诱导细胞死亡。低通量（460 nm，4 mW cm（-2）持续10分钟）。此外，TPCI可以实时自我监测细胞死亡。它在辐射前在活细胞中微弱地发出荧光，并在PDT处理过程中通过与染色质结合以激活其聚集诱导的发射，从而点亮细胞核，这归因于其与DNA的强结合亲和力。使用荷有H22和B16F10肿瘤细胞的小鼠模型进行的体内研究验证了TPCI的超高效PDT功效以及从癌症治疗开始就精确实时地无创读取肿瘤反应。双重功能的TPCI是单药光动力学治疗学的极佳候选者，这项工作代表了开发具有多种内在功能的分子以用于未来的自我报告医学应用的新范例。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号