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Peptide Programmed Hydrogels as Safe Sanctuary Microenvironments for Cell Transplantation

机译：肽编程水凝胶可作为细胞移植的安全庇护微环境

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摘要

Cell transplantation is one of the most promising strategies for the minimally invasive treatment of a raft of injuries and diseases. However, a standing challenge to its efficacy is poor cell survival due to a lack of mechanical protection during administration and an unsupportive milieu thereafter. In response, a shear-injectable nanoscaffold vector is engineered considering the three equal requirements of protection, support, and survival. Here, the programmed peptide assembly of tissue-specific epitopes presents a safe sanctuary microenvironment for the transplantation of cells. For the first time, a mechanistic understanding of the multifactorial role of the nanoscaffold in promoting cell survival is presented, where initial cell survival is dependent on the fluid mechanic process of droplet formation rather than on shear rate. However, provided is the first report of the most critical component of a transplantation vector, distinguishing feigned biological support from mechanical properties from true ongoing biological support post transplantation. This is achieved via the presentation of amino acid constituents that significantly improve the efficacy of the vector compared to a biocompatible, yet inert analogue. Together, the peptide-programmed hydrogels enable fundamental rules for the engineering of advanced treatment strategies with wide reaching implications for tissue repair and biofabrication.
机译：细胞移植是微创治疗损伤和疾病的最有前途的策略之一。然而，由于在给药过程中缺乏机械保护以及随后的无支撑环境，对其功效的长期挑战是细胞存活较差。作为响应，考虑了保护，支持和生存这三个相等的要求，设计了可剪切注射的纳米支架载体。在这里，组织特异性表位的程序化肽组装为细胞移植提供了安全的避难所微环境。首次提出了对纳米支架在促进细胞存活中的多重作用的机理的理解，其中初始细胞存活取决于液滴形成的流体力学过程而不是剪切速率。但是，本文提供了关于移植载体最关键成分的第一份报告，该报告将假装的生物学支持与机械性能与真正的正在进行的生物学支持从移植后的性能中区分开来。这是通过与生物相容但惰性的类似物相比，显着改善载体功效的氨基酸成分的呈现而实现的。一起，肽程序设计的水凝胶为高级治疗策略的工程设计提供了基本规则，对组织修复和生物制造具有广泛的影响。

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