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Photoactive Nanocarriers for Controlled Delivery

机译：用于控制传递的光敏纳米载体

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Photoactive nanocarriers have emerged as robust and minimally invasive systems for the on-demand delivery of active payloads. The easy manipulation offered by light irradiation as an external stimulus allows precise spatiotemporal control of payload release based on the time, intensity, location, and wavelength of light exposure. Compared to conventional passive delivery systems, photoactive nanocarriers offer the possibility of tailoring the release kinetics of the encapsulated active molecules, which is of considerable clinical relevance for targeted delivery to desired sites of interest. In this progress report, the recent advances in the design and fabrication of photoactive nanoplatforms based on three main modes of mechanisms: photochemical reactions, the photothermal effect, and photosensitization mechanism mediated by reactive oxygen species are highlighted. The combination of these mechanisms provides additional flexibility for the effective delivery of therapeutics and improved synergistic therapeutic effects. Finally, challenges in future perspectives on the development of photoactive nanomaterials and their medical translation are discussed.
机译：光活性纳米载体已经成为用于按需递送活性有效载荷的坚固且微创的系统。通过光照射作为外部刺激，操作简便，可根据曝光时间，强度，位置和波长精确控制时空释放。与常规的被动递送系统相比，光敏纳米载体提供了调节包封的活性分子的释放动力学的可能性，这对于靶向递送到所需的感兴趣部位具有相当大的临床意义。在此进展报告中，着重介绍了基于三种主要机理模式在光活性纳米平台的设计和制造方面的最新进展：光化学反应，光热效应和活性氧介导的光敏化机理。这些机制的组合为有效递送治疗剂和改善的协同治疗效果提供了额外的灵活性。最后，讨论了光敏纳米材料及其医学翻译的未来发展前景。

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