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Detecting the Origin of Cancer-Mobile Quantum Probe for Single Cancer Stem Cell Detection

机译：用于单癌症干细胞检测的癌症移动量子探针的起源检测

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摘要

Cancer stem cells (CSC) are believed to be the driving force of cancer metastases and are a rare population of self-renewing cells that contribute majorly to the poor outcomes of cancer therapy. The detection of CSC is of utmost importance to shed light on the indestructible nature of certain solid tumors and their metastatic ability. However, tumors tend to harbor CSCs in a specialized niche, making the detection process difficult. Currently, there is no method available to detect CSCs. The significance of this work is twofold. First, to the best of the knowledge, it is the first time that the detection of CSC is demonstrated. This approach simultaneously detects both the phenotypic and the metabolic state of the cell, thus enabling universal detection of CSC with high accuracy. Second, to the best of the knowledge, for the first time, light is shed on cell chemistry of CSC in their dedicated niche to facilitate a better understanding of the key players involved in the metabolic rewiring of CSC. This work will enable a better understanding of the fundamentals of CSCs, which are critical for the early diagnosis of cancer and the development of therapies for the cure of cancer.
机译：癌症干细胞（CSC）被认为是癌症转移的驱动力，并且是很少见的自我更新细胞群体，这些细胞主要导致癌症治疗效果差。 CSC的检测对于阐明某些实体瘤的坚不可摧性质及其转移能力至关重要。但是，肿瘤倾向于在特殊的环境中携带CSC，从而使检测过程变得困难。当前，没有可用的方法来检测CSC。这项工作的意义是双重的。首先，就其所知，这是第一次证明CSC的检测。该方法同时检测细胞的表型和代谢状态，从而能够以高精度对CSC进行通用检测。其次，就其所知，这是第一次，他们专门研究了CSC的细胞化学，以促进对CSC代谢重新连接所涉及的关键参与者的更好了解。这项工作将使人们更好地了解CSC的基础知识，这对于癌症的早期诊断和癌症治疗方法的发展至关重要。

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  • 来源
    《Advanced Functional Materials》 |2020年第9期|1907572.1-1907572.20|共20页
  • 作者

    Ganesh Swarna; Venkatakrishnan Krishnan; Tan Bo;

  • 作者单位

    Inst Biomed Engn Sci & Technol Toronto ON M5B 1W8 Canada|Ryerson Univ Ultrashort Laser Nanomfg Res Facil Dept Mech & Ind Engn 350 Victoria St Toronto ON M5B 2K3 Canada|Ryerson Univ Nano Bio Interface Facil Dept Mech & Ind Engn 350 Victoria St Toronto ON M5B 2K3 Canada;

    Ryerson Univ Ultrashort Laser Nanomfg Res Facil Dept Mech & Ind Engn 350 Victoria St Toronto ON M5B 2K3 Canada|Ryerson Univ Nano Bio Interface Facil Dept Mech & Ind Engn 350 Victoria St Toronto ON M5B 2K3 Canada|St Michaels Hosp Keenan Res Ctr 209 Victoria St Toronto ON M5B 1T8 Canada;

    Ryerson Univ Nano Bio Interface Facil Dept Mech & Ind Engn 350 Victoria St Toronto ON M5B 2K3 Canada|St Michaels Hosp Keenan Res Ctr 209 Victoria St Toronto ON M5B 1T8 Canada|Ryerson Univ Nanocharacterizat Lab Dept Aerosp Engn 350 Victoria St Toronto ON M5B 2K3 Canada;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    cancer detection; cancer stem cells; CSC; single cell SERS detection;

    机译：癌症检测;癌症干细胞CSC;单细胞SERS检测;

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