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A Novel Double-Crosslinking-Double-Network Design for Injectable Hydrogels with Enhanced Tissue Adhesion and Antibacterial Capability for Wound Treatment

机译：具有增强的组织粘附力和伤口处理抗菌能力的可注射水凝胶的新型双交联双网络设计。

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摘要

Most photocrosslinkable hydrogels have inadequacy in either mechanical performance or biodegradability. This issue is addressed by adopting a novel hydrogel design by introducing two different chitosan chains (catechol-modified methacryloyl chitosan, CMC; methacryloyl chitosan, MC) via the simultaneous crosslinking of carbon-carbon double bonds and catechol-Fe3+ chelation. This leads to an interpenetrating network of two chitosan chains with high crosslinking-network density, which enhances mechanical performance including high compressive modulus and high ductility. The chitosan polymers not only endow the hydrogels with good biodegradability and biocompatibility, they also offer intrinsic antibacterial capability. The quinone groups formed by Fe3+ oxidation and protonated amino groups of chitosan polymer further enhance antibacterial property of the hydrogels. Serving as one of the two types of crosslinking mechanisms, the catechol-Fe3+ chelation can covalently link with amino, thiol, and imidazole groups, which substantially enhance the hydrogel's adhesion to biological tissues. The hydrogel's adhesion to porcine skin shows a lap shear strength of 18.1 kPa, which is 6-time that of the clinically established Fibrin Glue's adhesion. The hydrogel also has a good hemostatic performance due to the superior tissue adhesion as demonstrated with a hemorrhaging liver model. Furthermore, the hydrogel can remarkably promote healing of bacteria-infected wound.
机译：大多数可光交联的水凝胶在机械性能或生物降解性方面均不足。通过采用新颖的水凝胶设计来解决此问题，该设计通过引入两个不同的壳聚糖链（邻苯二酚改性的甲基丙烯酰壳聚糖，CMC；甲基丙烯酰壳聚糖，MC），同时进行碳-碳双键交联和邻苯二酚-Fe3 +螯合。这导致具有高交联网络密度的两条壳聚糖链互穿网络，从而增强了机械性能，包括高压缩模量和高延展性。壳聚糖聚合物不仅赋予水凝胶良好的生物降解性和生物相容性，而且还具有内在的抗菌能力。 Fe3 +氧化形成的醌基和壳聚糖聚合物的质子化氨基进一步增强了水凝胶的抗菌性能。儿茶酚-Fe3 +螯合是两种交联机制之一，可与氨基，硫醇和咪唑基共价连接，从而大大增强了水凝胶对生物组织的粘附力。水凝胶对猪皮肤的粘附力显示出18.1 kPa的搭接剪切强度，是临床上确定的纤维蛋白胶粘附力的6倍。如出血性肝模型所示，由于优异的组织粘附性，水凝胶还具有良好的止血性能。此外，水凝胶可显着促进细菌感染伤口的愈合。

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  • 来源
    《Advanced Functional Materials》 |2020年第1期|1904156.1-1904156.14|共14页
  • 作者

    Wang Lei; Zhang Xuehui; Yang Kun; Fu Yu Vincent; Xu Tianshun; Li Shengliang; Zhang Dawei; Wang Lu-Ning; Lee Chun-Sing;

  • 作者单位

    Univ Sci & Technol Beijing Sch Mat Sci & Engn Beijing Adv Innovat Ctr Mat Genome Engn 30 Xueyuan Rd Beijing 100083 Peoples R China|City Univ Hong Kong Ctr Super Diamond & Adv Films COSDAF Kowloon 83 Tat Chee Ave Hong Kong Peoples R China|City Univ Hong Kong Dept Chem Kowloon 83 Tat Chee Ave Hong Kong Peoples R China;

    Peking Univ Sch & Hosp Stomatol Dept Dent Mat Zhongguancun South Ave 22 Beijing 100081 Peoples R China|Peking Univ Sch & Hosp Stomatol NMPA Key Lab Dent Mat Zhongguancun South Ave 22 Beijing 100081 Peoples R China|Peking Univ Sch & Hosp Stomatol Dent Med Devices Testing Ctr Zhongguancun South Ave 22 Beijing 100081 Peoples R China;

    Univ Sci & Technol Beijing Sch Mat Sci & Engn Beijing Adv Innovat Ctr Mat Genome Engn 30 Xueyuan Rd Beijing 100083 Peoples R China;

    Univ Chinese Acad Sci Chinese Acad Sci Savaid Med Sch State Key Lab Microbial Resources Inst Microbiol Beijing 100101 Peoples R China;

    City Univ Hong Kong Ctr Super Diamond & Adv Films COSDAF Kowloon 83 Tat Chee Ave Hong Kong Peoples R China|City Univ Hong Kong Dept Chem Kowloon 83 Tat Chee Ave Hong Kong Peoples R China;

    Univ Sci & Technol Beijing Ctr Corros & Protect 30 Xueyuan Rd Beijing 100083 Peoples R China;

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  • 正文语种 eng
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  • 关键词

    antibacterial capability; double-crosslinking-double-network; photocrosslinkable and injectable chitosan; tissue adhesion; wound healing;

    机译：抗菌能力;双交联双网;可光交联和注射的壳聚糖;组织粘附;伤口愈合;

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