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首页> 外文期刊>Advanced Functional Materials >Advanced Functional Materials and Cell-Based Therapies for the Treatment of Ischemic Stroke and Postischemic Stroke Effects
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Advanced Functional Materials and Cell-Based Therapies for the Treatment of Ischemic Stroke and Postischemic Stroke Effects

机译：先进的功能材料和基于细胞的疗法，用于治疗缺血性中风和缺血后中风

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Ischemic stroke is considered one of the most threatening neurological disorders with high percentages of mortality and morbidity worldwide. Although in recent years, several nanotechnological advances have improved the survival rates, severe untreated poststroke side-effects continue to significantly influence the way of life of many. Tissue plasminogen activator and mechanical thrombectomy are considered the gold standards for the treatment of acute cerebral ischemia. These, however, fail to improve postischemic disorders. Herein, after a brief description of the pathophysiology of ischemic stroke and the following biochemical cascade, the most recent biomaterial and cell-based strategies are reviewed for its treatment. Other therapeutics that have been proposed not only for the treatment of cerebral ischemia but also for the regeneration of the infarcted brain that is responsible for a variety of disorders, including cognitive, motor, and speech problems are also presented. Finally, a few reported studies on diagnostic and theranostic nanostructures are also provided.
机译：缺血性中风被认为是全球最具威胁性的神经系统疾病之一，死亡率和发病率很高。尽管近年来，几项纳米技术的进步提高了存活率，但严重的未经治疗的中风后副作用继续显着影响许多人的生活方式。组织纤溶酶原激活物和机械血栓切除术被认为是治疗急性脑缺血的金标准。然而，这些不能改善缺血后疾病。在此，在简要描述缺血性中风的病理生理学和随后的生化级联反应之后，对最新的基于生物材料和细胞的策略进行了综述。还提出了不仅建议用于治疗脑缺血，而且还建议用于引起多种疾病的梗塞性大脑再生的其他疗法，包括认知，运动和言语问题。最后，还提供了一些有关诊断和治疗纳米结构的报道研究。

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