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Toxico-Metabolomics of Engineered Nanomaterials: Progress and Challenges

机译：工程纳米材料的毒物代谢：进展和挑战

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摘要

Nanoscale matter has unique attributes that potentiate their widespread application from biomedicine, engineering, food, cosmetics, sensing, to energy. Due to the rapid industrialization of engineered nanomaterials (ENMs) as a result of increasing consumer interests, more ENMs will be released into the environment, greatly increasing the probability of their contact with humans. Once these ENMs enter the human body or an ecosystem, they may initiate various biochemical responses in unprecedented ways, thus raising important concerns in regard to their effects on human health and the ecosystem. Here, the shifts in the intricate metabolic pathways instigated by ENMs are highlighted and those altered metabolic changes are extrapolated for the elucidation of environmental health and risk assessment. Furthermore, the toxico-metabolomics knowledge of ENMs provides the opportunity to design novel nanomedicine with high efficacies by capitalizing on their abilities to rewire metabolic networks for the treatment of diseases.
机译：纳米级物质具有独特的属性，可增强其在生物医学，工程学，食品，化妆品，传感和能源领域的广泛应用。由于不断增长的消费者兴趣导致工程纳米材料（ENM）的快速工业化，更多的ENM将被释放到环境中，从而大大增加了它们与人类接触的可能性。这些ENM进入人体或生态系统后，它们可能会以前所未有的方式引发各种生化反应，从而引起人们对它们对人类健康和生态系统的影响的重要关注。在此，突出显示了由ENM引起的复杂代谢途径的变化，并推断出那些改变的代谢变化，以阐明环境健康和风险评估。此外，ENMs的毒物代谢知识使他们有机会利用其重新连接代谢网络以治疗疾病的能力，设计出高效的新型纳米药物。

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