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首页> 外文期刊>Advanced Functional Materials >Printed Conformable Liquid Metal e-Skin-Enabled Spatiotemporally Controlled Bioelectromagnetics for Wireless Multisite Tumor Therapy
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Printed Conformable Liquid Metal e-Skin-Enabled Spatiotemporally Controlled Bioelectromagnetics for Wireless Multisite Tumor Therapy

机译：用于无线多站点肿瘤治疗的印刷适形液态金属电子皮肤启用时空控制生物电磁学

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摘要

With inherent flexibility, high electroconductivity, excellent thermal conductivity, easy printability and biosafety, gallium-based functional liquid metals (LMs) have been increasingly evaluated for biomedical applications, especially as electronic skin (e-skin). Extending these versatile materials to more challenging applications is a worthwhile pursuit. To realize precise and spatiotemporal multisite tumor treatment under an alternating magnetic field (AMF), an oxidized GaIn (O-GaIn) mixture-based e-skin is developed and demonstrated to be printable. Compared with the commonly utilized non-oxidized GaIn, O-GaIn possesses outstanding adhesion to the skin surface and can be directly and quickly printed into various customized patterns. The LM e-skin thus constructed as conformable bioelectrodes on tumor-bearing mice exhibits evident feasibility for administrating non-invasive wireless multisite tumor therapy under AMF exposure due to its favorable magnetothermal effects. These in vivo experiments reveal remarkable tumor growth inhibition and increased life span in mice, especially in the case of multilesion treatment. A favorable biomedical strategy based on O-GaIn material for developing future non-invasive and high-performance cancer therapy, which is also promising for treating whole-body diseases in the future, is provided.
机译：镓基功能性液态金属（LMs）具有固有的柔韧性，高导电性，优异的导热性，易印刷性和生物安全性，因此越来越多地用于生物医学应用，尤其是电子皮肤（e-s-kin）的镓基液态金属（LMs）的评估。将这些通用材料扩展到更具挑战性的应用程序是值得追求的。为了在交变磁场（AMF）下实现精确的时空多部位肿瘤治疗，开发了一种基于氧化GaIn（O-GaIn）混合物的电子皮肤，并证明其可打印。与常用的非氧化GaIn相比，O-GaIn对皮肤表面具有出色的附着力，可以直接，快速地打印成各种定制图案。如此构造为荷瘤小鼠上的生物电极的LM e-皮肤由于其良好的磁热效应，显示了在AMF暴露下进行非侵入性无线多部位肿瘤治疗的明显可行性。这些体内实验显示出了显着的肿瘤生长抑制作用，并延长了小鼠的寿命，尤其是在多病变治疗的情况下。提供了一种基于O-GaIn材料的有利生物医学策略，用于开发未来的非侵入性和高性能癌症疗法，这也有望在将来治疗全身疾病。

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  • 来源
    《Advanced Functional Materials》 |2019年第51期|1907063.1-1907063.13|共13页
  • 作者

    Wang Xuelin; Fan Linlin; Zhang Jie; Sun Xuyang; Chang Hao; Yuan Bo; Guo Rui; Duan Minghui; Liu Jing;

  • 作者单位

    Tsinghua Univ Sch Med Dept Biomed Engn Beijing 100084 Peoples R China;

    Chinese Acad Med Sci Dept Radiol Natl Ctr Cardiovasc Dis Fuwai Hosp Peking Union Med Coll Beijing 100037 Peoples R China;

    Chinese Acad Sci Tech Inst Phys & Chem Beijing Key Lab CryoBiomed Engn Beijing 100190 Peoples R China|Chinese Acad Sci Tech Inst Phys & Chem Key Lab Cryogen Beijing 100190 Peoples R China;

    Tsinghua Univ Sch Med Dept Biomed Engn Beijing 100084 Peoples R China|Chinese Acad Sci Tech Inst Phys & Chem Beijing Key Lab CryoBiomed Engn Beijing 100190 Peoples R China|Chinese Acad Sci Tech Inst Phys & Chem Key Lab Cryogen Beijing 100190 Peoples R China;

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  • 正文语种 eng
  • 中图分类
  • 关键词

    Conformable liquid metal; e-skin; direct printing; multisite tumor therapy; oxidized GaIn;

    机译：合适的液态金属;电子皮肤直接印刷;多部位肿瘤治疗;氧化镓铟;

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