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首页> 外文期刊>Advanced Functional Materials >Heterotargeted Nanococktail with Traceless Linkers for Eradicating Cancer
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Heterotargeted Nanococktail with Traceless Linkers for Eradicating Cancer

机译：具有无痕连接子的异源靶向纳米鸡尾酒，用于根除癌症

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摘要

Clinical application of drug cocktails for cancer therapy is limited by their severe systemic toxicity. To solve a catch-22 dilemma between safety and efficacy for drug cocktails, a heterotargeted nanococktail (PPPDMA) with traceless linkers is developed. In the PPPDMA nanogel, a heterotargeting strategy is employed to improve its tumor selective targeting efficacy by overcoming the cancer cell monoligand density limitation. Benefitting from its glutathione and reactive oxygen species responsiveness, the loaded paclitaxel and doxorubicin can be quickly and tracelessly released into the cytoplasm in their original form, which bestows upon PPPDMA nanogels the capability to overwhelm the processing capacity of the cancer cell's P-glycoprotein efflux pump, and ultimately kill them without inducing side effects. The PPPDMA treatment reduced its tumor burden over 99% (in tumor weight) and 96% (in tumor number). Most importantly, no detectable tumor in more than half of the PPPDMA treated mice was observed. It is concluded that traceless linker and heterotargeted nanococktail strategy can be a safe and effective approach for cancer treatment.
机译：药物混合物用于癌症治疗的临床应用受到其严重的全身毒性的限制。为了解决药物鸡尾酒的安全性和功效之间的陷阱22难题，开发了具有无痕连接子的异标纳米鸡尾酒（PPPDMA）。在PPPDMA纳米凝胶中，通过克服癌细胞单配体密度限制，采用异质靶向策略来提高其肿瘤选择性靶向功效。受益于其谷胱甘肽和活性氧物种的响应性，负载的紫杉醇和阿霉素可以以其原始形式快速无痕地释放到细胞质中，这赋予PPPDMA纳米凝胶以压倒癌细胞P-糖蛋白外排泵的处理能力的能力。 ，最终杀死它们而不会引起副作用。 PPPDMA治疗将其肿瘤负担降低了99％（以肿瘤重量计）和96％（以肿瘤数计）。最重要的是，在超过一半的PPPDMA处理的小鼠中未观察到可检测到的肿瘤。结论是，无痕连接子和异源纳米鸡尾酒策略可以是一种安全有效的癌症治疗方法。

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