• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Functional Materials >Unprecedented Theranostic LaB_6 Nanocubes-Mediated NIR-IIb Photodynamic Therapy to Conquer Hypoxia-Induced Chemoresistance
【24h】

Unprecedented Theranostic LaB_6 Nanocubes-Mediated NIR-IIb Photodynamic Therapy to Conquer Hypoxia-Induced Chemoresistance

机译：前所未有的治疗Lab_6纳米尺介导的尼鲁 - IIB光动力学疗法，以征服缺氧诱导的化学化学

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Tumor hypoxia and chemoresistance are long-lasting challenges in clinical cancer treatments resulting in treatment failures and low patient survival rates. Application of phototherapies to treat deep tissue-buried tumors has been hampered by the lack of near infrared photosensitizers, and consumption of tissue oxygen, worsening the tumor hypoxia problem. Herein, an unprecedented theranostic lanthanum hexaboride-based nanodrug is engineered to act as bimodal computed tomographic/magnetic resonance imaging contrast agents, absorb long near infrared (NIR) light in the biological window IIb (1500-1700 nm), generate hydroxyl radicals without using oxygen, and destroy drug-resistant NCI-H23 lung tumors completely, leading to an amazingly long average half-life of 180 days, far exceeding than those of doxorubicin-treated (21 days) and untreated mice groups (13 days). This work pioneers the field of photodynamic therapy in conquering hypoxia and chemodrug resistance problems for NIR-IIb oxygen-independent cancer treatments.
机译：肿瘤缺氧和化学抑制性是临床癌症治疗中的持久挑战，导致治疗失败和低患者存活率。光疗法在缺乏近红外光敏剂和组织氧气消耗的情况下阻碍了深层组织埋下的肿瘤，缺乏肿瘤缺氧的消耗。在此，工程化的前所未有的硫替镧系六硼烷基·纳米醇以用作双峰计算的层析性/磁共振成像造影剂，吸收生物窗口IIb（1500-1700nm）中的长近红外（NIR）光，而不会使用羟基自由基氧气，并完全破坏耐药性NCI-H23肺肿瘤，导致普通寿命的惊人半衰期为180天，远远超过多柔比蛋白治疗（21天）和未经处理的小鼠（13天）。这项工作开创了光动力学疗法领域，征服了缺氧和化学内节抗性问题的缺氧抗血氧性癌症治疗方法。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号