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首页> 外文期刊>Advanced Functional Materials >Bioprinting Tissue Analogues with Decellularized Extracellular Matrix Bioink for Regeneration and Tissue Models of Cartilage and Intervertebral Discs
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Bioprinting Tissue Analogues with Decellularized Extracellular Matrix Bioink for Regeneration and Tissue Models of Cartilage and Intervertebral Discs

机译：Bioplulting组织类似物，具有脱细胞外基质的生物链接，用于软骨和椎间盘的组织模型

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摘要

The recent convergence of decellularized extracellular matrix (dECM) methodologies and 3D bioprinting (3DBP) has led to multiple advancements in tissue engineering scaffold design by enabling researchers to recreate a tissue-specific 3D environment in a custom geometry. The application of 3DBP of dECM for articular cartilage and intervertebral disc (IVD) repair, however, is still burgeoning. While cartilage and IVD tissue each possess unique architectures, they are composed of similar macromolecules and therefore pose similar challenges for the successful application of their matrix bioinks. Herein, the state-of-the-art in cartilage and IVD dECM bioink preparation, material properties, and applications are highlighted. The current major obstacles regarding optimal decellularization and printing methods are discussed, which need to be overcome to enable recapitulation of the hierarchical organization, zone-specific matrix composition, and anisotropic biomechanical behavior of the native tissues. Finally, a vision is presented for how this field may continue to evolve in the future to empower the fabrication of scaffolds that serve as effective templates for guiding cellular assembly and organization toward the formation of functional cartilage and IVD tissues.
机译：最近的渐变细胞外基质（DECM）方法和3D BioPrinting（3DBP）的收敛已经通过使研究人员在定制几何形状中重新创建组织特异性的3D环境来导致组织工程脚手架设计的多次进步。然而，在关节软骨和椎间盘（IVD）修复中的3DBP应用仍然是蓬勃发展的。虽然软骨和IVD组织各自拥有独特的架构，但它们由类似的大分子组成，因此对其矩阵生物链接的成功应用构成类似的挑战。这里，突出了在软骨和IVD DECM生物晶芯制剂，材料特性和应用中的最先进的。讨论了关于最佳脱细胞化和印刷方法的目前的主要障碍，需要克服，以便能够培养分层组织，特异性基质组合物和本地组织的各向异性生物力学行为。最后，展示了这种领域如何在将来继续发展的愿景，以赋予用作引导蜂窝组装和组织朝向形成功能性软骨和IVD组织的有效模板的支架的制造。

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