Biomaterials for Sequestration of Growth Factors and Modulation of Cell Behavior

Teixeira Simao P. B.; Domingues Rui M. A.; Shevchuk Mariya; Gomes Manuela E.; Peppas Nicholas A.; Reis Rui L.

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Biomaterials for Sequestration of Growth Factors and Modulation of Cell Behavior

机译：用于封存生长因子的生物材料和细胞行为的调节

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Growth factors (GFs) are proteins secreted by cells that regulate a variety of biological processes. Although they have long been proposed as potent therapeutic agents, their administration in a soluble form has proven costly and ineffective due to their short half-lives in biological environments. Biomaterial-based approaches are increasingly sought as alternatives to improve the efficacy or, ideally, replace the need for exogenous administration of GFs in regenerative medicine strategies. The means by which these systems evolve from biomaterials for conventional controlled release of GFs to the recent extracellular matrix (ECM)-inspired approaches for sequestering these labile molecules and regulating their spatiotemporal activity and presentation are reviewed. Focus is placed on biomaterials functionalized either with ECM components, which show promiscuous GF binding, or with targeted GF ligands (antibodies, aptamers, or peptides). The potential of synthetic platforms with abiotic affinity as cost-effective alternatives to the current biological ligands is also discussed. Overall, the various GF sequestering systems developed so far have remarkably improved the activity of GFs at reduced doses and, in some cases, completely avoided the need for their exogenous administration to guide cell fates. These bioinspired concepts thus enable the rational exploration of the full therapeutic potential of GFs in regenerative medicine.

机译：生长因子（GFS）是通过调节各种生物方法的细胞分泌的蛋白质。虽然它们已经长期提出为有效的治疗剂，但由于生物环境的短暂半衰期，它们以可溶性形式的施用成本昂贵和无效。越来越多地寻求基于生物材料的方法，以改善疗效或理想情况下，更换对再生医学策略的外源性GFS的需要。综述了这些系统从用于近期细胞外基质（ECM）的近期细胞外基质（ECM）的方法的生物材料的方法进行综合进行螯合和调节它们的时空活性和介绍的近期细胞外基质（ECM）的方法。将焦点放在官能化的生物材料上，其具有ECM组分，其显示混杂的GF结合，或靶向GF配体（抗体，适体或肽）。还讨论了具有非生物亲和力的合成平台作为当前生物配体的经济效益替代品的潜力。总的来说，到目前为止开发的各种GF螯合系统在减少剂量下显着改善了GFS的活性，并且在某些情况下，完全避免了它们的外源给药以引导细胞命运。因此，这些生物悬浮的概念使得能够在再生医学中对GFS的全部治疗潜力的合理探索。

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来源
《Advanced Functional Materials》 |2020年第44期|1909011.1-1909011.26|共26页
作者
Teixeira Simao P. B.; Domingues Rui M. A.; Shevchuk Mariya; Gomes Manuela E.; Peppas Nicholas A.; Reis Rui L.;
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Univ Minho I3Bs Res Inst Biomat Biodegradables & Biomimet Headquarters European Inst Excellence Tissue Engn 3Bs Res Grp AvePk Parque Ciencia & Tecnol P-4805017 Guimaraes Portugal|ICVS 3Bs PT Govt Associate Lab Braga Guimaraes Portugal|Univ Minho Discoveries Ctr Regenerat & Precis Med AvePk P-4805017 Barco Guimaraes Portugal;

Univ Minho I3Bs Res Inst Biomat Biodegradables & Biomimet Headquarters European Inst Excellence Tissue Engn 3Bs Res Grp AvePk Parque Ciencia & Tecnol P-4805017 Guimaraes Portugal|ICVS 3Bs PT Govt Associate Lab Braga Guimaraes Portugal|Univ Minho Discoveries Ctr Regenerat & Precis Med AvePk P-4805017 Barco Guimaraes Portugal;

Univ Texas Austin McKetta Dept Chem Engn Austin TX 78712 USA|Univ Texas Austin Inst Biomat Drug Delivery & Regenerat Med Austin TX 78712 USA|Univ Texas Austin Dept Biomed Engn Austin TX 78712 USA|Univ Texas Austin Med Sch Dept Pediat Austin TX 78712 USA|Univ Texas Austin Med Sch Dept Surg & Perioperat Care Austin TX 78712 USA|Univ Texas Austin Coll Pharm Div Mol Pharmaceut & Drug Delivery Austin TX 78712 USA;

Univ Minho I3Bs Res Inst Biomat Biodegradables & Biomimet Headquarters European Inst Excellence Tissue Engn 3Bs Res Grp AvePk Parque Ciencia & Tecnol P-4805017 Guimaraes Portugal|ICVS 3Bs PT Govt Associate Lab Braga Guimaraes Portugal|Univ Minho Discoveries Ctr Regenerat & Precis Med AvePk P-4805017 Barco Guimaraes Portugal;

Univ Texas Austin McKetta Dept Chem Engn Austin TX 78712 USA|Univ Texas Austin Inst Biomat Drug Delivery & Regenerat Med Austin TX 78712 USA|Univ Texas Austin Dept Biomed Engn Austin TX 78712 USA|Univ Texas Austin Med Sch Dept Pediat Austin TX 78712 USA|Univ Texas Austin Med Sch Dept Surg & Perioperat Care Austin TX 78712 USA|Univ Texas Austin Coll Pharm Div Mol Pharmaceut & Drug Delivery Austin TX 78712 USA;

Univ Minho I3Bs Res Inst Biomat Biodegradables & Biomimet Headquarters European Inst Excellence Tissue Engn 3Bs Res Grp AvePk Parque Ciencia & Tecnol P-4805017 Guimaraes Portugal|ICVS 3Bs PT Govt Associate Lab Braga Guimaraes Portugal|Univ Minho Discoveries Ctr Regenerat & Precis Med AvePk P-4805017 Barco Guimaraes Portugal;

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正文语种 eng
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关键词
affinity binding; biomaterials; growth factors; molecular recognition; stem cells;

机译：亲和力结合;生物材料;生长因子;分子识别;干细胞;

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2. Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta [J] . Catherine Baugé, Olivier Cauvard, Sylvain Leclercq, Arthritis Research . 2011,第1期

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3. Modulation of the effects of FSH, androstenedione, epidermal growth factor (EGF) and insulin-like growth factor I (IGF-I) on bovine granulosa cells by GCIF, a growth-inhibitory factor of low molecular mass from bovine follicular fluid [J] . A. C. Hynes, J. M. Sreenan, M. T. Kane Journal of reproduction and fertility . 1996,第2期

机译：通过GCIF调节FSH，雄烯二酮，表皮生长因子（EGF）和胰岛素样生长因子I（IGF-1）对牛颗粒细胞的作用，GCIF是一种来自牛卵泡液的低分子量生长抑制因子
4. Modifying Biomaterials to Regulate Cell Behavior: Controlled Binding and Release of Growth Factors for Cartilage Tissue Engineering [C] . S. Degala, j. Tsui, S. Milton, Annual meeting exposition of the Controlled Release Society . 2011

机译：修改生物材料来调节细胞行为：软骨组织工程的受控结合和生长因子的释放。
5. Modulation of Vascular Cell Specific Growth: Electroceutical Mechanisms and Biomaterial Constructs [D] . Ammann, Kaitlyn R. 2018

机译：血管细胞特异性生长的调节：电学机制和生物材料的构造。
6. Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta [O] . Catherine Baugé, Olivier Cauvard, Sylvain Leclercq, 2011

机译：通过在人骨关节炎软骨细胞中转化生长因子β来调节转化生长因子β信号通路基因的调节：Sp1在早期和晚期应答细胞中对转化生长因子β的参与
7. Biomaterials for Sequestration of Growth Factors and Modulation of Cell Behavior [O] . Simão P. B. Teixeira, Rui M. A. Domingues, Mariya Shevchuk, 2020

机译：用于封存生长因子的生物材料和细胞行为的调节

Biomaterials for Sequestration of Growth Factors and Modulation of Cell Behavior

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