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Advanced Strategies for Modulation of the Material-Macro phage Interface

机译：用于调制材料 - 宏噬菌体界面的高级策略

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摘要

Biomaterials are becoming increasingly crucial for healthcare solutions, with extensive use in the field of tissue engineering and drug delivery. After implantation, biomaterials trigger an immune response characterized by the recruitment of bone-marrow-derived proinflammatory macrophages that develop as the most abundant cell type surrounding the biomaterial. Chronic activation of this recruited macrophage population induces a foreign body reaction response and consequent biomaterial rejection. However, transition toward a proreparative phenotype is associated with biomaterial integration and tissue homeostasis restoration. In this review, the most relevant strategies that modulate biomaterial immune response are discussed, including mechanical properties, surface coatings, release of anti-inflammatory molecules and cytokines, antibacterial features, origin and inner moieties of biomaterials, and cell crosstalk. Moreover, the role of tissue resident macrophages, an embryo-derived macrophage population with a strong reparative potential, in promoting biomaterial tolerance will be reviewed. This provides new insights to better tune the reaction of the host immune system to implanted biomaterials in order to favor integration and increase the knowledge of macrophages as key players in tissue homeostasis.
机译：生物材料对于医疗保健解决方案越来越重要，在组织工程和药物递送领域广泛使用。植入后，生物材料引发了一种免疫应答，其特征在于招募骨髓衍生的促炎巨噬细胞，这些巨噬细胞发展为围绕生物材料周围的最丰富的细胞类型。该募集的巨噬细胞人群的慢性激活诱导异物反应反应和随后的生物材料排斥。然而，朝向前症表型转变与生物材料整合和组织稳态恢复有关。在该综述中，讨论了调节生物材料免疫反应的最相关的策略，包括机械性能，表面涂层，抗炎分子释放，生物材料和细胞串扰的细胞因子，抗菌特征，原产地和内部部分。此外，将综述组织常规巨噬细胞，胚胎巨噬细胞群的作用，促进促进生物材料耐受性强的潜力。这提供了新的见解，更好地调节宿主免疫系统对植入生物材料的反应，以便有利于集成并增加巨噬细胞的知识作为组织稳态中的关键参与者。

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  • 来源
    《Advanced Functional Materials》 |2020年第44期|1909331.1-1909331.21|共21页
  • 作者

    Huyer Locke Davenport; Pascual-Gil Simon; Wang Yufeng; Mandla Serena; Yee Bess; Radisic Milica;

  • 作者单位

    Univ Toronto Dept Chem Engn & Appl Chem Toronto ON M5S 3E5 Canada|Univ Toronto Inst Biomat & Biomed Engn Toronto ON M5S 3G9 Canada|Univ Hlth Network Toronto Gen Res Inst Toronto ON M5G 2C4 Canada;

    Univ Toronto Inst Biomat & Biomed Engn Toronto ON M5S 3G9 Canada|Univ Hlth Network Toronto Gen Res Inst Toronto ON M5G 2C4 Canada;

    Univ Toronto Dept Chem Engn & Appl Chem Toronto ON M5S 3E5 Canada|Univ Hlth Network Toronto Gen Res Inst Toronto ON M5G 2C4 Canada;

    Univ Toronto Inst Biomat & Biomed Engn Toronto ON M5S 3G9 Canada|Univ Hlth Network Toronto Gen Res Inst Toronto ON M5G 2C4 Canada;

    Univ Hlth Network Toronto Gen Res Inst Toronto ON M5G 2C4 Canada;

    Univ Toronto Dept Chem Engn & Appl Chem Toronto ON M5S 3E5 Canada|Univ Toronto Inst Biomat & Biomed Engn Toronto ON M5S 3G9 Canada|Univ Hlth Network Toronto Gen Res Inst Toronto ON M5G 2C4 Canada;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    biomaterials; host response; immunoengineering; macrophages;

    机译：生物材料;宿主响应;免疫工程;巨噬细胞;

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