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Piezoelectric Nano-Biomaterials for Biomedicine and Tissue Regeneration

机译：生物医学和组织再生的压电纳米生物材料

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摘要

Among various classes of biomaterials, the majority of non-centrosymmetric crystalline materials exhibit piezoelectric properties, i.e., the accumulation of charge in response to applied mechanical stress or deformation. Due to the growing interest in nanomaterials, piezoelectric nano-biomaterials have been widely investigated, leading to remarkable advancements throughout the last two decades. Piezoelectric properties, high surface energy, targeting properties, and intricate cell-material interactions render piezoelectric nanomaterials highly attractive for application in therapeutics as well as regenerative medicine. Herein, the major focus is to highlight the wide range of applications of piezoelectric nano-biomaterials in drug delivery, theranostics, and tissue regeneration. After a brief introduction to piezoelectricity, an overview is provided on the major classes of piezoelectric biomaterials as well as a description of the origin of biopiezoelectricity in different tissues and macromolecules. Subsequently, relevant properties and postfabrication strategies of nanostructured piezoelectric biomaterials are discussed aiming to maximize piezoresponse. Finally, recent studies on nano- piezoceramics and piezopolymers are presented, with specific focus on barium titanate, zinc oxide, and polyvinylidene fluoride.
机译：在各种类别的生物材料中，大多数非邻摩尔晶体材料表现出压电性能，即响应于施加的机械应力或变形而累积电荷。由于对纳米材料的兴趣日益生长，压电纳米生物材料已被广泛研究，在过去二十年中导致卓越的进步。压电性能，高表面能，靶向性能和复杂的细胞材料相互作用使压电纳米材料具有高度吸引力的治疗剂和再生药物。在此，主要重点是突出压电纳米生物材料在药物递送，治中和组织再生中的广泛应用。在简要介绍压电之后，在主要类压电生物材料的主要类别中提供了概述，以及不同组织和大分子的BioPiezo电征的起源。随后，讨论了纳米结构压电生物材料的相关性质和后缔约方策略，旨在最大化压电响应。最后，介绍了最近对纳米压电陶瓷和压电聚合物的研究，具有特异性聚焦钛酸钡，氧化锌和聚偏二氟乙烯。

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