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首页> 外文期刊>Advanced Functional Materials >Cell and Tissue Instructive Materials for Central Nervous System Repair
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Cell and Tissue Instructive Materials for Central Nervous System Repair

机译：用于中枢神经系统修复的细胞和组织指导材料

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摘要

Neurodegenerative disorders and traumatic events affecting the central nervous system (CNS) represent one of the main health problems nowadays. The level of disability and impairment of these patients is very high, both at physiological and psychological level, drastically altering a person's lifestyle. The fact that CNS tissue has a limited capacity of regeneration has hampered the development of possible therapies to these conditions. The specificity of each disease also increases the complexity of creating strategies capable of inducing significant recovery. Therefore, the search for a solution for these problems most likely demands a combinatorial approach that integrates knowledge from different fields. Tissue engineering and regenerative medicine (TERM) concepts merge areas such as biology, chemistry, physics, or biomaterials science, and it is a strong candidate for CNS applications. In particular, the development of cell and tissue instructive materials (CTIMs) can bring new opportunities for the treatment of these conditions. In this review, the authors summarize and discuss the most recent advances in the development of CTIMs for CNS applications, focusing on traumatic conditions such as spinal cord injuy, traumatic brain injuy, but also stroke, and other neurodegenerative diseases such as Alzheimer's and Parkinson's disease as well as multiple sclerosis.
机译：影响中枢神经系统（CNS）的神经变性障碍和创伤事件现在代表了如今的主要健康问题之一。这些患者的残疾水平和损伤在生理和心理层面都很高，彻底改变了一个人的生活方式。 CNS组织具有有限的再生能力的事实阻碍了对这些条件的可能疗法的发展。每种疾病的特异性也增加了产生能够诱导显着恢复的策略的复杂性。因此，对这些问题的寻找解决方案最有可能要求集成来自不同领域的知识的组合方法。组织工程和再生医学（术语）概念合并生物学，化学，物理学或生物材料科学等领域，并且是CNS应用的强大候选者。特别是，细胞和组织有效材料（CTIMS）的发展可以为治疗这些条件带来新的机会。在本次审查中，作者总结和讨论了CNS应用程序开发的最新进展，重点关注脊髓损伤，创伤性脑受伤等创伤条件，也是中风，以及其他神经变性疾病，如Alzheimer和Parkinson病以及多发性硬化症。

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  • 来源
    《Advanced Functional Materials》 |2020年第44期|1909083.1-1909083.26|共26页
  • 作者

    Rocha Luis A.; Silva Deolinda; Barata-Antunes Sandra; Cavaleiro Helena; Gomes Eduardo D.; Silva Nuno A.; Salgado Antonio J.;

  • 作者单位

    Univ Minho Sch Med Life & Hlth Sci Res Inst ICVS Campus Gualtar P-4710057 Braga Portugal|ICVS 3Bs PT Govt Associate Lab Braga Portugal;

    Univ Minho Sch Med Life & Hlth Sci Res Inst ICVS Campus Gualtar P-4710057 Braga Portugal|ICVS 3Bs PT Govt Associate Lab Braga Portugal;

    Univ Minho Sch Med Life & Hlth Sci Res Inst ICVS Campus Gualtar P-4710057 Braga Portugal|ICVS 3Bs PT Govt Associate Lab Braga Portugal;

    Univ Minho Sch Med Life & Hlth Sci Res Inst ICVS Campus Gualtar P-4710057 Braga Portugal|ICVS 3Bs PT Govt Associate Lab Braga Portugal;

    Univ Minho Sch Med Life & Hlth Sci Res Inst ICVS Campus Gualtar P-4710057 Braga Portugal|ICVS 3Bs PT Govt Associate Lab Braga Portugal;

    Univ Minho Sch Med Life & Hlth Sci Res Inst ICVS Campus Gualtar P-4710057 Braga Portugal|ICVS 3Bs PT Govt Associate Lab Braga Portugal;

    Univ Minho Sch Med Life & Hlth Sci Res Inst ICVS Campus Gualtar P-4710057 Braga Portugal|ICVS 3Bs PT Govt Associate Lab Braga Portugal;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    biomaterials; central nervous system; neurodegenerative diseases; tissue instructive materials; trauma;

    机译：生物材料;中枢神经系统;神经变性疾病;组织有效材料;创伤;

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