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首页> 外文期刊>Advanced Functional Materials >High Fidelity Bidirectional Neural Interfacing with Carbon Fiber Microelectrodes Coated with Boron-Doped Carbon Nanowalls: An Acute Study
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High Fidelity Bidirectional Neural Interfacing with Carbon Fiber Microelectrodes Coated with Boron-Doped Carbon Nanowalls: An Acute Study

机译：碳纤维微电极涂有硼掺杂碳纳米瓦尔的高保真双向神经界面：急性研究

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摘要

Implantable electrodes that can communicate with a small, selective group of neurons via both neural stimulation and recording are critical for the development of advanced neuroprosthetic devices. Microfiber electrodes with neuron-scale cross-sections have the potential to improve the spatial resolution for both stimulation and recording, while minimizing the chronic inflammation response after implantation. In this work, glass insulated microfiber electrodes are fabricated by coating carbon fibers with boron-doped carbon nanowalls. The coating significantly improves the electrochemical properties of carbon fibers, leading to a charge injection capacity of 7.82 +/- 0.35 mC cm(-2), while retaining good flexibility, stability and biocompatibility. When used for neural interfacing, the coated microelectrodes successfully elicit localized stimulation responses in explanted retina, and are also able to detect signals from single neurons, in vivo with a signal-to-noise ratio as high as 6.7 in an acute study. This is the first report of using carbon nanowall coated carbon fibers for neural interfacing.
机译：可以通过神经刺激和记录与小型选择性神经元进行通信的可植入电极对先进的神经治疗装置的开发至关重要。具有神经元级横截面的微纤维电极具有改善刺激和记录的空间分辨率，同时植入后最小化慢性炎症反应。在这项工作中，通过用硼掺杂的碳纳米瓦尔涂覆碳纤维来制造玻璃绝缘微纤维电极。涂层显着改善了碳纤维的电化学性能，导致电荷注入容量为7.82 +/- 0.35mc（-2），同时保持良好的柔韧性，稳定性和生物相容性。当用于神经连接时，涂覆的微电极在外部视网膜中成功地引发了局部刺激反应，并且还能够在急性研究中以高达6.7的信噪比检测来自单个神经元的信号。这是使用碳纳米醛涂层碳纤维进行神经接口的第一报告。

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  • 来源
    《Advanced Functional Materials》 |2020年第52期|2006101.1-2006101.10|共10页
  • 作者

    Hejazi Maryam A.; Tong Wei; Stacey Alastair; Sun Shi H.; Yunzab Molis; Almasi Ali; Jung Young Jun; Meffin Hamish; Fox Kate; Edalati Khatereh; Nadarajah Athavan; Prawer Steven; Ibbotson Michael R.; Garrett David. J.;

  • 作者单位

    Univ Melbourne Sch Phys Parkville Vic 3010 Australia;

    Univ Melbourne Sch Phys Parkville Vic 3010 Australia|Australian Coll Optometry Natl Vis Res Inst Carlton Vic 3053 Australia|Univ Melbourne Dept Optometry & Vis Sci Parkville Vic 3010 Australia;

    Univ Melbourne Sch Phys Parkville Vic 3010 Australia|RMIT Univ Sch Sci Melbourne Vic 3000 Australia;

    Australian Coll Optometry Natl Vis Res Inst Carlton Vic 3053 Australia;

    Australian Coll Optometry Natl Vis Res Inst Carlton Vic 3053 Australia;

    Australian Coll Optometry Natl Vis Res Inst Carlton Vic 3053 Australia;

    Australian Coll Optometry Natl Vis Res Inst Carlton Vic 3053 Australia|Univ Melbourne Dept Optometry & Vis Sci Parkville Vic 3010 Australia;

    Australian Coll Optometry Natl Vis Res Inst Carlton Vic 3053 Australia|Univ Melbourne Dept Optometry & Vis Sci Parkville Vic 3010 Australia;

    RMIT Univ Sch Engn Melbourne Vic 3000 Australia|RMIT Univ Ctr Addit Mfg Melbourne Vic 3000 Australia;

    Univ Melbourne Sch Phys Parkville Vic 3010 Australia;

    Univ Melbourne Sch Phys Parkville Vic 3010 Australia;

    Univ Melbourne Sch Phys Parkville Vic 3010 Australia;

    Australian Coll Optometry Natl Vis Res Inst Carlton Vic 3053 Australia|Univ Melbourne Dept Optometry & Vis Sci Parkville Vic 3010 Australia;

    Univ Melbourne Sch Phys Parkville Vic 3010 Australia|RMIT Univ Sch Engn Melbourne Vic 3000 Australia;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    carbon fiber; carbon nanowall; implantable; recording; stimulation;

    机译：碳纤维;碳纳米瓦尔;植入;录音;刺激;

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