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Shape Transformable Strategies for Drug Delivery

机译：形状可转化的药物交付策略

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摘要

In tumor therapy, nanodrug delivery systems have gained momentum in the last decade. However, its efficacy remains insufficient for clinical applications. The physical properties of nanoparticles, including size, shape, and surface characteristics, can strongly affect the delivery efficacy. Ironically, research on shape function is relatively scarce, although the nanoparticle shape greatly impacts their performance; for example, nanorods with a high aspect ratio (AR) achieve greater accumulation, but their penetration is relatively weak. Hence, rather than selecting a suitable AR to balance them, the strategy of a transformable AR (i.e., transformation) is ideal in this case. Nanoparticle transformation can be achieved by either internal stimuli (such as pH and enzymes) or external stimuli (such as light) spatially and temporally with precision, thereby dramatically enhancing the efficiency of drug delivery. Thus, nanoparticle transformation is becoming a promising prospect for improving cancer treatment. In this review, first, the effect of shape on drug delivery is summarized, then, the recently transformable drug delivery systems are reviewed, and finally, the future direction of shape-transformable nanoparticles in tumor therapy is discussed.
机译：在肿瘤疗法中，纳米德鲁格递送系统在过去十年中获得了动量。然而，它的疗效仍然不足以用于临床应用。纳米颗粒的物理性质，包括尺寸，形状和表面特性，可以强烈影响递送功效。具有讽刺意味的是，对形状功能的研究相对稀缺，尽管纳米粒子造型极大地影响了它们的性能;例如，具有高纵横比（AR）的纳米棒实现更大的积累，但它们的渗透率相对较弱。因此，不是选择合适的AR来平衡它们，而是可变形的AR（即转换）的策略在这种情况下是理想的。纳米颗粒转化可以通过在空间和时间的外部刺激（如pH和酶）或外部刺激（如光）以精确度，从而显着提高药物递送的效率。因此，纳米粒子转化正在成为改善癌症治疗的有希望的前景。在本文中，首先，综述了对药物递送的形状对药物递送的影响，讨论了最近可转化的药物递送系统，最后，讨论了肿瘤治疗中的可变形纳米粒子的未来方向。

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  • 来源
    《Advanced Functional Materials》 |2021年第18期|2009765.1-2009765.23|共23页
  • 作者

    Jia Wenfeng; Wang Yushan; Liu Rui; Yu Xiangrong; Gao Huile;

  • 作者单位

    Sichuan Univ West China Sch Pharm Key Lab DrugTargeting & Drug Delivery Syst Sichuan Engn Lab PlantSourced Drug Educ Minist Chengdu 610064 Peoples R China|Sichuan Univ West China Sch Pharm Sichuan Res Ctr Drug Precis Ind Technol Chengdu 610064 Peoples R China;

    Sichuan Univ West China Sch Pharm Key Lab DrugTargeting & Drug Delivery Syst Sichuan Engn Lab PlantSourced Drug Educ Minist Chengdu 610064 Peoples R China|Sichuan Univ West China Sch Pharm Sichuan Res Ctr Drug Precis Ind Technol Chengdu 610064 Peoples R China;

    Sichuan Univ West China Sch Pharm Key Lab DrugTargeting & Drug Delivery Syst Sichuan Engn Lab PlantSourced Drug Educ Minist Chengdu 610064 Peoples R China|Sichuan Univ West China Sch Pharm Sichuan Res Ctr Drug Precis Ind Technol Chengdu 610064 Peoples R China;

    Jinan Univ Zhuhai Peoples Hosp Dept Radiol Zhuhai 519000 Peoples R China;

    Sichuan Univ West China Sch Pharm Key Lab DrugTargeting & Drug Delivery Syst Sichuan Engn Lab PlantSourced Drug Educ Minist Chengdu 610064 Peoples R China|Sichuan Univ West China Sch Pharm Sichuan Res Ctr Drug Precis Ind Technol Chengdu 610064 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    drug delivery; responsive system; shape transformation; tumor treatment;

    机译：药物递送;响应系统;形状转化;肿瘤治疗;

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