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首页> 外文期刊>Advanced Functional Materials >Green Tea Derivative Driven Smart Hydrogels with Desired Functions for Chronic Diabetic Wound Treatment
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Green Tea Derivative Driven Smart Hydrogels with Desired Functions for Chronic Diabetic Wound Treatment

机译：绿茶衍生物驱动智能水凝胶，具有慢性糖尿病伤口治疗的所需功能

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摘要

Current treatments for chronic diabetic wounds remain unsatisfactory due to the lack of ideal wound dressings that can integrate matching mechanical strength, fast self-healability, facile dressing change, and multiple therapeutic effects into one system. In this work, benefiting from the catechol groups and therapeutic effect of epigallocatechin-3-gallate (EGCG, green tea derivative), a smart hydrogel dressing can be conveniently obtained through copolymerization of the complex formed by EGCG and 3-acrylamido phenylboronic acid (APBA) (the formation of boronate ester bond) and acrylamide. The resulting hydrogel features adequate mechanical properties, self-healing capability, and tissue adhesiveness. Otherwise, the substantial release of EGCG can not only realize anti-oxidation, antibacterial, anti-inflammatory and proangiogenic effect, and modulation of macrophage polarization to accelerate wound healing, but also facilitate easy dressing change. This advanced hydrogel provides a facile and effective way for diabetic chronic wound management and may be extended for the therapy of other complicated wound healings.
机译：由于缺乏理想的伤口敷料，目前对慢性糖尿病伤口的目前的治疗仍然不令人满意，可以将匹配的机械强度，快速的自我康复性，容易的敷料变化和多种治疗效果集成到一个系统中。在这项工作中，受益于儿茶酚基团和EPIGALLOCATECHIN-3-Gallate（EGCG，绿茶衍生物）的治疗效果，可以通过EGCG和3-丙基酰胺苯基硼酸形成的复合物（APBA）的复合物（APBA）方便地获得智能水凝胶敷料）（形成硼酸酯键）和丙烯酰胺。所得水凝胶具有足够的机械性能，自愈合能力和组织粘合性。否则，EGCG的大量释放不仅可以实现抗氧化，抗菌，抗炎和致泌发效果，以及调节巨噬细胞极化以加速伤口愈合，还促进了易于敷料的变化。这种先进的水凝胶为糖尿病慢性伤口管理提供了一种容易而有效的方法，可以延长其他复杂伤口愈合的治疗。

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  • 来源
    《Advanced Functional Materials》 |2021年第18期|2009442.1-2009442.14|共14页
  • 作者

    Zhao Xiaodan; Pei Dandan; Yang Yuxuan; Xu Kai; Yu Jing; Zhang Yuchen; Zhang Qiang; He Gang; Zhang Yanfeng; Li Ang; Cheng Yilong; Chen Xuesi;

  • 作者单位

    Xi An Jiao Tong Univ Coll Stomatol Key Lab Shaanxi Prov Craniofacial Precis Med Res Xian 710049 Peoples R China;

    Xi An Jiao Tong Univ Coll Stomatol Key Lab Shaanxi Prov Craniofacial Precis Med Res Xian 710049 Peoples R China;

    Xi An Jiao Tong Univ Coll Stomatol Key Lab Shaanxi Prov Craniofacial Precis Med Res Xian 710049 Peoples R China;

    Xi An Jiao Tong Univ Sch Chem Xian 710049 Peoples R China;

    Xi An Jiao Tong Univ Sch Chem Xian 710049 Peoples R China;

    Xi An Jiao Tong Univ Coll Stomatol Key Lab Shaanxi Prov Craniofacial Precis Med Res Xian 710049 Peoples R China;

    Xi An Jiao Tong Univ Sch Chem Xian 710049 Peoples R China;

    Xi An Jiao Tong Univ Frontier Inst Sci & Technol Xian 710049 Peoples R China;

    Xi An Jiao Tong Univ Sch Chem Xian 710049 Peoples R China;

    Xi An Jiao Tong Univ Coll Stomatol Key Lab Shaanxi Prov Craniofacial Precis Med Res Xian 710049 Peoples R China;

    Xi An Jiao Tong Univ Sch Chem Xian 710049 Peoples R China;

    Chinese Acad Sci Changchun Inst Appl Chem Key Lab Polymer Ecomat Changchun 13022 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    boronate ester; chronic diabetic wound; green tea derivative; hydrogel; self-healing;

    机译：硼酸酯;慢性糖尿病伤口;绿茶衍生物;水凝胶;自我愈合;

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