Engineered Nanoscale Vanadium Metallodrugs for Robust Tumor-Specific Imaging and Therapy

Li Shihua; Chen Yongling; Zhu Wei; Yang Wen; Chen Zhaowei; Song Jibin; Song Xiaorong; Chen Xian; Yang Huanghao

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Engineered Nanoscale Vanadium Metallodrugs for Robust Tumor-Specific Imaging and Therapy

机译：工程化纳米级钒Metallodrug用于鲁棒肿瘤特异性成像和治疗

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Therapeutic metallodrugs have gained substantial success in cancer treatment and also motivate the active exploration of metallodrugs for cancer theranostics. However, it remains a challenge to engineer metallodrugs with desired therapy efficacy and safety because of their frequent in vivo limited bioavailability and off-target delivery. Herein, an efficient strategy to design vanadium nanodrugs (VNDs) with cancer-specific theranostic capability for visualizing/treating in vivo mice tumors, is developed. The VNDs are controllably constructed via a non-covalent coordination triggered self-assembly strategy, which allows the general synthesis of diverse nanoscale metallodrugs. Significantly, the VNDs exert an approximately tenfold enhancement of therapy efficacy in comparison with vanadium compounds and the clinically used cisplatin due to their improved bioavailability and multiple pathways-mediated tumor-selective therapy. Moreover, the VNDs feature intense near-infrared (NIR) absorption and undergo specific disassembly in the tumor microenvironment, thus enabling tumor-specific molecular imaging by the turn-on NIR fluorescence of embedded labels upon disassembly. Hence, the vanadium nanoprodrugs propose a new paradigm for in vivo tumor-selective therapy and imaging and may propel the design of effective anticancer metallodrugs.

机译：治疗性金属石油蛋白在癌症治疗中取得了大量成功，并且还促使Metallodrugs对癌症治疗的积极探索。然而，由于它们在体内有限的生物利用度和脱靶递送中常见，因此对工程效果和安全性具有所需治疗效果和安全性仍然是挑战。在此，开发了一种有效的培养型纳米细胞（VND）具有用于在体内小鼠肿瘤中可视化/治疗的癌症特异性治疗能力的有效策略。 VND可通过非共价协调触发的自组装策略控制，允许各种纳米级金属糖尿病的一般合成。值得注意的是，与钒化合物和临床使用的顺铂相比，VNDS施加疗效的大约十倍提高了治疗效果，这是由于其改善的生物利用度和多种途径介导的肿瘤选择性治疗。此外，VNDS特征在肿瘤微环境中具有强烈的近红外（NIR）吸收和经历特异性拆卸，从而通过拆卸时通过嵌入标签的开启NIR荧光进行肿瘤特异性分子成像。因此，钒NanoProdrodrugs提出了一种新的范例，用于体内肿瘤选择性治疗和成像，并且可以推动有效的抗癌茂金属的设计。

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来源
《Advanced Functional Materials》 |2021年第17期|2010337.1-2010337.9|共9页
作者
Li Shihua; Chen Yongling; Zhu Wei; Yang Wen; Chen Zhaowei; Song Jibin; Song Xiaorong; Chen Xian; Yang Huanghao;
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Fuzhou Univ Coll Chem State Key Lab Photocatalysis Energy & Environm MOE Key Lab Analyt Sci Food Safety & Biol Fuzhou 350108 Peoples R China;

Fuzhou Univ Coll Chem State Key Lab Photocatalysis Energy & Environm MOE Key Lab Analyt Sci Food Safety & Biol Fuzhou 350108 Peoples R China;

Fuzhou Univ Coll Chem State Key Lab Photocatalysis Energy & Environm MOE Key Lab Analyt Sci Food Safety & Biol Fuzhou 350108 Peoples R China;

Fuzhou Univ Coll Chem State Key Lab Photocatalysis Energy & Environm MOE Key Lab Analyt Sci Food Safety & Biol Fuzhou 350108 Peoples R China;

Fuzhou Univ Coll Chem State Key Lab Photocatalysis Energy & Environm MOE Key Lab Analyt Sci Food Safety & Biol Fuzhou 350108 Peoples R China;

Fuzhou Univ Coll Chem State Key Lab Photocatalysis Energy & Environm MOE Key Lab Analyt Sci Food Safety & Biol Fuzhou 350108 Peoples R China;

Fuzhou Univ Coll Chem State Key Lab Photocatalysis Energy & Environm MOE Key Lab Analyt Sci Food Safety & Biol Fuzhou 350108 Peoples R China|Fujian Sci & Technol Innovat Lab Optoelect Inform Fuzhou 350108 Peoples R China;

Fuzhou Univ Coll Chem State Key Lab Photocatalysis Energy & Environm MOE Key Lab Analyt Sci Food Safety & Biol Fuzhou 350108 Peoples R China;

Fuzhou Univ Coll Chem State Key Lab Photocatalysis Energy & Environm MOE Key Lab Analyt Sci Food Safety & Biol Fuzhou 350108 Peoples R China|Fujian Sci & Technol Innovat Lab Optoelect Inform Fuzhou 350108 Peoples R China;

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正文语种 eng
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关键词
fluorescence imaging; metallodrug; nanomedicine; tumor therapy; vanadium;

机译：荧光成像;Metallodrug;Nanomedicine;肿瘤治疗;钒;

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Engineered Nanoscale Vanadium Metallodrugs for Robust Tumor-Specific Imaging and Therapy

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