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首页> 外文期刊>Advanced Functional Materials >A Hierarchical Janus Nanofibrous Membrane Combining Direct Osteogenesis and Osteoimmunomodulatory Functions for Advanced Bone Regeneration
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A Hierarchical Janus Nanofibrous Membrane Combining Direct Osteogenesis and Osteoimmunomodulatory Functions for Advanced Bone Regeneration

机译：一种分层Janus纳米纤维膜，结合直接骨发生和骨瘤术术进行先进骨再生功能

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摘要

An ideal guided bone regeneration membrane (GBRM) is expected not only to perform barrier function, but also to enhance osteogenesis and resist bacteria infection. However, currently available membranes have limited bioactivities. To address this challenge, a Janus GBRM (JGM) is designed and fabricated by sequential fractional electrospinning here. The random gelatin fibers loaded with hydroxyapatite (HAP) are designed as the inner face to promote the osteoblasts' adhesion, proliferation, and osteogenic differentiation, meanwhile the aligned poly(caprolactone) (PCL) nanofibers loaded with poly(methacryloxyethyltrimethyl ammonium chloride-co-2-Aminoethyl 2-methylacrylate hydrochloride) (P(DMC-AMA)) are designed as the outer layer to resist epithelia invasion and bacterial infection. In vitro assays reveal that the inner face displays enhanced osteogenic effects, meanwhile the outer surface can regulate the epithelia to spread along the aligned direction and kill the contacted bacteria. Interestingly, the outer face can induce macrophages to polarize toward the M2 phenotype, thus manipulating a favorable osteoimmune environment. These results suggest that the JGM simultaneously meets the critical requirements of barrier, osteogenic, antibacterial, and osteoimmunomodulatory functions. Consequently, the JGM shows better in vivo bone tissue regeneration performance than the commercial Bio-Gide membrane. This work provides a novel platform to design multi-functional membranes/scaffolds, displaying great potential applications in tissue engineering.
机译：期望理想的引导骨再生膜（GBRM）不仅要进行屏障功能，还可以增强成骨和抗蚀剂感染。然而，目前可用的膜具有有限的生物活跃。为了解决这一挑战，Janus GBRM（JGM）是通过在此处顺序的静电纺丝设计和制造的。装有羟基磷灰石（HAP）的随机明胶纤维被设计为内表面，以促进成骨细胞的粘附，增殖和成骨分化，同时配合用聚（甲基丙烯酰氧基甲基三甲基氯化铵 - COM）的对齐的聚（己内酮）（PCL）纳米纤维2-氨基乙基2-甲基丙烯酸盐盐酸盐）（P（DMC-AMA））设计为外层以抵抗上皮侵袭和细菌感染。体外测定揭示内表面显示出增强的成骨效果，同时外表面可以调节上皮沿着对齐方向扩散并杀死接触的细菌。有趣的是，外表面可以诱导巨噬细胞偏振朝向M2表型偏振，从而操纵有利的骨瘤环境。这些结果表明，JGM同时满足屏障，成骨，抗菌和骨瘤组织功能的关键要求。因此，JGM在比商业生物基辅膜的体内骨组织再生性能较好。这项工作提供了一种设计多功能膜/脚手架的新颖平台，在组织工程中显示出巨大的潜在应用。

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  • 来源
    《Advanced Functional Materials》 |2021年第8期|2008906.1-2008906.12|共12页
  • 作者

    Wang Qian; Feng Yunbo; He Min; Zhao Weifeng; Qiu Li; Zhao Changsheng;

  • 作者单位

    Sichuan Univ Coll Polymer Sci & Engn State Key Lab Polymer Mat Engn Chengdu 610065 Peoples R China;

    Sichuan Univ Coll Polymer Sci & Engn State Key Lab Polymer Mat Engn Chengdu 610065 Peoples R China;

    Sichuan Univ West China Hosp Stomatol State Key Lab Oral Dis Chengdu 610041 Sichuan Peoples R China;

    Sichuan Univ Coll Polymer Sci & Engn State Key Lab Polymer Mat Engn Chengdu 610065 Peoples R China;

    Sichuan Univ West China Sch Med Dept Ultrasound West China Hosp Chengdu 610041 Peoples R China;

    Sichuan Univ Coll Polymer Sci & Engn State Key Lab Polymer Mat Engn Chengdu 610065 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    antibacterial; electrospinning; guided bone regeneration; osteogenesis; osteoimmunomodulation;

    机译：抗菌;静电纺丝;引导骨再生;成骨;骨瘤杂作用;

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