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首页> 外文期刊>Advanced Functional Materials >2D Core/Shell-Structured Mesoporous Silicene@Silica for Targeted and Synergistic NIR-Ⅱ-Induced Photothermal Ablation and Hypoxia-Activated Chemotherapy of Tumors
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2D Core/Shell-Structured Mesoporous Silicene@Silica for Targeted and Synergistic NIR-Ⅱ-Induced Photothermal Ablation and Hypoxia-Activated Chemotherapy of Tumors

机译：2D核心/壳结构的中孔硅胶@二氧化硅靶向和协同NIR-Ⅱ诱导的肿瘤的光热消融和缺氧激活化学疗法

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摘要

Silicene nanosheets, the emerging 2D nanomaterial, as the third topology of silicon-composed materials with distinct physicochemical properties, is a desirable candidate for photothermal-conversion nanoagent (PTA) and drug-delivery nanosystems. Inspired by the individual physiochemical properties and structure features of mesoporous silica and 2D silicene, a distinctive 2D core/shell-structured multifunctional silicon-composed theranostic nanoplatform (Silicene@Silica) is constructed by coating a mesoporous silica layer onto the surface of 2D silicene nanosheets. The well-defined mesopores originating from mesoporous silica shell provide the reservoirs for guest drug molecules and the core of silicene produces heat shock upon NIR-II laser irradiation, aiming to induce the synergistic cancer-therapeutic modality. Importantly, when AQ4N, hypoxia-activated prodrug, is introduced into this system, this nanoplatform (Silicene@Silica-AQ4N) exhibits tumor microenvironment (TME)-responsive and synergistic hyperthermia-augmented therapeutic bioactivity. Such a nanoplatform can amplify the hypoxia of TME by destroying the tumor microcirculation and then further efficiently activate AQ4N, a DNA affinity agent and topoisomerase II inhibitor. The results reveal that this multifunctional theranostic nanoplatform can efficiently eliminate tumors without recurrence.
机译：硅氧烷纳米片，新出现的2D纳米材料，作为具有不同物理化学性质的硅组合材料的第三拓扑，是用于光热转化纳释（PTA）和药物 - 产物纳米系统的理想候选者。通过介孔二氧化硅和2D硅的个体物理化学性质和结构特征的启发，通过将介孔二氧化硅层涂覆到2D硅纳米晶片表面上，构建独特的2D芯/壳结构的多功能硅（硅胶）构成了独特的2D芯/壳结构的多功能硅（硅胶）。 。源于中孔二氧化硅壳的明确定义的甲泡为客体药物分子提供储存器，硅的核心在NIR-II激光照射时产生热冲击，旨在诱导协同癌症治疗方式。重要的是，当将AQ4N，活化的前药引入该系统时，该纳米载物（硅胶@ Silica-AQ4N）表现出肿瘤微环境（TME） - 响应和协同高温增强治疗生物活性。这种纳米纳米甲型可以通过破坏肿瘤微循环来扩增TME的缺氧，然后进一步有效地活化AQ4N，DNA亲和剂和拓扑异构酶II抑制剂。结果表明，这种多功能的治疗纳米纳薄型可以有效地消除肿瘤而不会复发。

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  • 来源
    《Advanced Functional Materials》 |2021年第24期|2102043.1-2102043.15|共15页
  • 作者

    Yin Haohao; Zhou Bangguo; Zhao Chongke; Sun Liping; Yue Wenwen; Li Xiaolong; Li Hongyan; Li Shaoyue; Xu Huixiong; Chen Yu;

  • 作者单位

    Tongji Univ Shanghai Peoples Hosp 10 Sch Med Shanghai Engn Res Ctr Ultrasound Diag & T Canc Ctr Dept Med Ultrasound Ultrasound Res & Edu Shanghai 200072 Peoples R China;

    Tongji Univ Shanghai Peoples Hosp 10 Sch Med Shanghai Engn Res Ctr Ultrasound Diag & T Canc Ctr Dept Med Ultrasound Ultrasound Res & Edu Shanghai 200072 Peoples R China;

    Tongji Univ Shanghai Peoples Hosp 10 Sch Med Shanghai Engn Res Ctr Ultrasound Diag & T Canc Ctr Dept Med Ultrasound Ultrasound Res & Edu Shanghai 200072 Peoples R China;

    Tongji Univ Shanghai Peoples Hosp 10 Sch Med Shanghai Engn Res Ctr Ultrasound Diag & T Canc Ctr Dept Med Ultrasound Ultrasound Res & Edu Shanghai 200072 Peoples R China;

    Tongji Univ Shanghai Peoples Hosp 10 Sch Med Shanghai Engn Res Ctr Ultrasound Diag & T Canc Ctr Dept Med Ultrasound Ultrasound Res & Edu Shanghai 200072 Peoples R China;

    Tongji Univ Shanghai Peoples Hosp 10 Sch Med Shanghai Engn Res Ctr Ultrasound Diag & T Canc Ctr Dept Med Ultrasound Ultrasound Res & Edu Shanghai 200072 Peoples R China;

    Tongji Univ Shanghai Peoples Hosp 10 Sch Med Shanghai Engn Res Ctr Ultrasound Diag & T Canc Ctr Dept Med Ultrasound Ultrasound Res & Edu Shanghai 200072 Peoples R China;

    Tongji Univ Shanghai Peoples Hosp 10 Sch Med Shanghai Engn Res Ctr Ultrasound Diag & T Canc Ctr Dept Med Ultrasound Ultrasound Res & Edu Shanghai 200072 Peoples R China;

    Tongji Univ Shanghai Peoples Hosp 10 Sch Med Shanghai Engn Res Ctr Ultrasound Diag & T Canc Ctr Dept Med Ultrasound Ultrasound Res & Edu Shanghai 200072 Peoples R China;

    Shanghai Univ Sch Life Sci Materdicine Lab Shanghai 200444 Peoples R China|Chinese Acad Sci Shanghai Inst Ceram State Key Lab High Performance Ceram & Superfine Shanghai 200050 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    AQ4N; hypoxia#8208; activated prodrugs; mesoporous silica; silicene; synergistic treatments;

    机译：aq4n;缺氧＆＃8208;活性前药;中孔二氧化硅;硅丁烯;协同治疗;

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