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首页> 外文期刊>Journal of Materials Chemistry, B. materials for biology and medicine >Graphene oxide coating core-shell silver sulfide@mesoporous silica for active targeted dual-mode imaging and chemo-photothermal synergistic therapy against tumors
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Graphene oxide coating core-shell silver sulfide@mesoporous silica for active targeted dual-mode imaging and chemo-photothermal synergistic therapy against tumors

机译：石墨烯氧化物涂料芯 - 壳银硫化物@中孔二氧化硅用于活性靶向双模影像和化学光热协同疗法对肿瘤

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摘要

The accurate treatment of tumors with the help of multimodality imaging is of great significance. Herein, a novel multifunctional probe combining active targeted fluorescent imaging (FL)/photoacoustic imaging (PA) and chemo-photothermal therapy for tumors has been designed. Targeting molecule folate (FA) modified graphene oxide (GO) was used to coat core-shell silver sulfide@mesoporous silica (QD@Si) while antitumoral doxorubicin (DOX) was loaded in mesoporous channels by electrostatic adhesion, and a delivery system (QD@Si-D/GO-FA) for active targeted dual-mode imaging and synergistic chemo-photothermal for tumors was successfully obtained. Experiments showed the cell survival rate was 76.3 +/- 4.6% when the probe concentration reached 0.5 mg mL(-1), and demonstrated that the probe had good biocompatibility. In vivo and in vitro results indicated that this probe could be used for active targeted FL/PA for tumors with overexpressed FA receptors. The temperature of the tumor rose to 63.5 degrees C under laser irradiation, and the tumor could be killed more effectively after combination with chemotherapy, which was caused by exfoliation of GO from QD@Si-D/GO-FA after irradiation. These results showed that the probe had great potential for application in oncology and is expected to provide evidence for early diagnosis and treatment of tumors.
机译：伴随多模式成像的准确治疗肿瘤的帮助具有重要意义。在此，已经设计了一种新的多功能探针，组合活性靶向荧光成像（FL）/光声成像（PA）和用于肿瘤的化学光热疗法。靶向分子叶酸（FA）改性的石墨烯氧化物（GO）用于涂上核 - 壳银硫化物@中壳二氧化硅（QD @ Si），同时通过静电粘合和输送系统（QD @ Si-D / Go-Fa）用于有源目标双模成像和用于肿瘤的协同化学光热。实验表明，当探针浓度达到0.5mg（-1）时，细胞存活率为76.3 +/- 4.6％，并证明探针具有良好的生物相容性。体内和体外结果表明，该探针可用于具有过表达FA受体的肿瘤的活性靶向FL / PA。激光照射下肿瘤的温度升至63.5摄氏度，并且在与化疗组合后，肿瘤可以更有效地杀死，这是由辐射后QD @ Si-D / Go-Fa的去角质引起的。这些结果表明，探针在肿瘤学中的应用有很大的潜力，预计将提供早期诊断和治疗肿瘤的证据。

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    Song Yuan-Yang; Li Cheng; Yang Xiao-Quan; An Jie; Cheng Kai; Xuan Yang; Shi Xue-Meng; Gao Meng-Juan; Song Xian-Lin; Zhao Yuan-Di; Chen Wei;

  • 作者单位

    Huazhong Univ Sci &

    Technol Collaborat Innovat Ctr Biomed Engn Coll Life Sci &

    Technol Britton Chance Ctr Biomed Wuhan Natl Lab Optoelect Hubei Bioinformat &

    Mol Wuhan 430074 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Collaborat Innovat Ctr Biomed Engn Coll Life Sci &

    Technol Britton Chance Ctr Biomed Wuhan Natl Lab Optoelect Hubei Bioinformat &

    Mol Wuhan 430074 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Collaborat Innovat Ctr Biomed Engn Coll Life Sci &

    Technol Britton Chance Ctr Biomed Wuhan Natl Lab Optoelect Hubei Bioinformat &

    Mol Wuhan 430074 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Collaborat Innovat Ctr Biomed Engn Coll Life Sci &

    Technol Britton Chance Ctr Biomed Wuhan Natl Lab Optoelect Hubei Bioinformat &

    Mol Wuhan 430074 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Collaborat Innovat Ctr Biomed Engn Coll Life Sci &

    Technol Britton Chance Ctr Biomed Wuhan Natl Lab Optoelect Hubei Bioinformat &

    Mol Wuhan 430074 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Collaborat Innovat Ctr Biomed Engn Coll Life Sci &

    Technol Britton Chance Ctr Biomed Wuhan Natl Lab Optoelect Hubei Bioinformat &

    Mol Wuhan 430074 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Collaborat Innovat Ctr Biomed Engn Coll Life Sci &

    Technol Britton Chance Ctr Biomed Wuhan Natl Lab Optoelect Hubei Bioinformat &

    Mol Wuhan 430074 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Collaborat Innovat Ctr Biomed Engn Coll Life Sci &

    Technol Britton Chance Ctr Biomed Wuhan Natl Lab Optoelect Hubei Bioinformat &

    Mol Wuhan 430074 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Key Lab Biomed Photon HUST Minist Educ Wuhan 430074 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Collaborat Innovat Ctr Biomed Engn Coll Life Sci &

    Technol Britton Chance Ctr Biomed Wuhan Natl Lab Optoelect Hubei Bioinformat &

    Mol Wuhan 430074 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Collaborat Innovat Ctr Biomed Engn Coll Life Sci &

    Technol Britton Chance Ctr Biomed Wuhan Natl Lab Optoelect Hubei Bioinformat &

    Mol Wuhan 430074 Hubei Peoples R China;

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  • 正文语种 eng
  • 中图分类 分析化学;
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