• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Functional Materials >Reshaping Antitumor Immunity with Chemo-Photothermal Integrated Nanoplatform to Augment Checkpoint Blockade-Based Cancer Therapy
【24h】

Reshaping Antitumor Immunity with Chemo-Photothermal Integrated Nanoplatform to Augment Checkpoint Blockade-Based Cancer Therapy

机译：用化学光热综合纳米片成重塑抗肿瘤免疫力，以增强基于检查点的癌症治疗

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Immune checkpoint therapy promotes cytotoxic T lymphocytes (CTLs) activity to eliminate tumors. Nevertheless, their effectiveness in solid tumors is limited by inadequate infiltration of CTLs and suppressive tumor microenvironment (TME). Herein, an anti-PD-1 antibody coupled chemo-photothermal integrated nanoplatform (A/Au@MSMs-P) is proposed to reshape antitumor immunity against cancer. The matrix metalloproteinase-2 (MMP-2) responsive A/Au@MSMs-P promotes the separation of abemaciclib-loaded gold-silica nanoparticles (A/Au@MSMs) and anti-PD-1 antibody, achieving a triple-coordinated strategy to enhance checkpoint blockade therapy. First, chemo-photothermal therapy of A/Au@MSMs induces cell cycle arrest in G1 phase and promotes tumor cells apoptosis to achieve local ablation. Second, immunogenic death of tumor cells promotes the maturation of dendritic cells and recruits antigen-specific CTLs into tumor tissue to promote immune activation. Third, abemaciclib markedly suppresses the proliferation of regulatory T cells (Tregs) to alleviate the immunosuppression of the TME and potentiates the effectiveness of CTLs. This triple-coordinated strategy not only reshapes the antitumor immunity to enhance checkpoint blockade, but also cooperates with chemo-photothermal therapy, leading to improved antitumor efficiency and prolonged survival rate. Taken together, this study presents a promising strategy for improving checkpoint therapy response and has great potential in future cancer therapy.
机译：免疫检查点治疗促进细胞毒性T淋巴细胞（CTLS）活性以消除肿瘤。然而，它们在固体肿瘤中的有效性受CTL和抑制肿瘤微环境（TME）的浸润不足的限制。在此，提出了一种抗PD-1抗体偶联的化学光热总体集成纳米膜（A / AU @ MSMS-P）以重塑抗癌的抗肿瘤免疫力。基质金属蛋白酶-2（MMP-2）响应A / AU @ MSMS-P促进厌氧加载的金 - 二氧化硅纳米粒子（A / AU @ MSM）和抗PD-1抗体的分离，实现三重协调的策略增强检查点阻断疗法。首先，A / AU @ MSMS的化疗 - 光热疗诱导G1相中细胞周期停滞，促进肿瘤细胞凋亡以实现局部消融。二，肿瘤细胞的免疫原性死亡促进树突细胞的成熟，并将抗原特异性CTL促进到肿瘤组织中以促进免疫激活。第三，ABEMACICLIB显着抑制调节性T细胞（TREGS）的增殖，以减轻TME的免疫抑制并增强CTL的有效性。这种三重协调的策略不仅重塑抗肿瘤免疫力以增强检查点延迟，还与化学光热疗法合作，导致抗肿瘤效率提高和延长的存活率。在一起，本研究提出了提高检查点治疗反应的有希望的策略，并在未来的癌症治疗中具有很大的潜力。

著录项

  • 来源
    《Advanced Functional Materials》 |2021年第28期|2100437.1-2100437.14|共14页
  • 作者

    Gao Tong; Zhang Zipeng; Liang Shuang; Fu Shunli; Mu Weiwei; Guan Li; Liu Yang; Chu Qihui; Fang Yuxiao; Liu Yongjun; Zhang Na;

  • 作者单位

    Shandong Univ Dept Pharmaceut Key Lab Chem Biol Sch Pharmaceut Sci Cheeloo Coll Med Minist Educ 44 Wenhua Xi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Dept Pharmaceut Key Lab Chem Biol Sch Pharmaceut Sci Cheeloo Coll Med Minist Educ 44 Wenhua Xi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Dept Pharmaceut Key Lab Chem Biol Sch Pharmaceut Sci Cheeloo Coll Med Minist Educ 44 Wenhua Xi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Dept Pharmaceut Key Lab Chem Biol Sch Pharmaceut Sci Cheeloo Coll Med Minist Educ 44 Wenhua Xi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Dept Pharmaceut Key Lab Chem Biol Sch Pharmaceut Sci Cheeloo Coll Med Minist Educ 44 Wenhua Xi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Dept Pharmaceut Key Lab Chem Biol Sch Pharmaceut Sci Cheeloo Coll Med Minist Educ 44 Wenhua Xi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Dept Pharmaceut Key Lab Chem Biol Sch Pharmaceut Sci Cheeloo Coll Med Minist Educ 44 Wenhua Xi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Dept Pharmaceut Key Lab Chem Biol Sch Pharmaceut Sci Cheeloo Coll Med Minist Educ 44 Wenhua Xi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Dept Pharmaceut Key Lab Chem Biol Sch Pharmaceut Sci Cheeloo Coll Med Minist Educ 44 Wenhua Xi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Dept Pharmaceut Key Lab Chem Biol Sch Pharmaceut Sci Cheeloo Coll Med Minist Educ 44 Wenhua Xi Rd Jinan 250012 Shandong Peoples R China;

    Shandong Univ Dept Pharmaceut Key Lab Chem Biol Sch Pharmaceut Sci Cheeloo Coll Med Minist Educ 44 Wenhua Xi Rd Jinan 250012 Shandong Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    abemaciclib; immune checkpoint therapy; immunogenic cell death; regulatory T cells; triple-coordinated strategy;

    机译：ABEMACICLIB;免疫检查点治疗;免疫原性细胞死亡;监管T细胞;三重协调战略;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号