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Aminoglycoside-Based Biomaterials: From Material Design to Antibacterial and Gene Delivery Applications

机译：基于氨基糖苷的生物材料：从材料设计到抗菌和基因递送应用

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摘要

Aminoglycosides are a family of naturally isolated or chemically semi-synthesized antibiotics consisting of aminocyclitols with several amino and saccharide units. The unique molecule structures render aminoglycosides promising building blocks with high reactivity to perform various non-covalent and covalent reactions, and they are further employed to rationally fabricate versatile materials, such as hydrogels, amphiphiles, hyperbranched polymers, biointerfaces, and nanoparticles. Despite aminoglycosides are widely used in clinics to treat bacterial infections, almost all the efforts are focused on molecular modifications to reduce their toxicities and overcome antibiotic resistance, while their actions as building blocks to construct biomaterials are scarcely discussed. In this feature article, the current progress on the rational design, emergent properties, and promising biological applications of aminoglycoside-based biomaterials are summarized. It is believed that this paper may provide guidance to develop new biomaterials using natural functional molecules as building blocks, and start a new life of aminoglycosides from the view of materials science.
机译：氨基糖苷是一种天然的分离或化学半合成抗生素的家族，由氨基环糖醇组成，具有几个氨基和糖类单元。独特的分子结构使氨基糖苷具有高反应性的氨基糖苷，其具有高反应性以进行各种非共价和共价反应，并且它们进一步用于合理制造通酯材料，例如水凝胶，两亲支，超支化聚合物，生物界面和纳米颗粒。尽管氨基糖苷被广泛用于治疗细菌感染，但几乎所有的努力都集中在分子修饰上，以减少毒性并克服抗生素抗性，而其作为构建生物材料构建生物材料的作用几乎没有讨论。在这一特征文章中，总结了基于甘氨酸基生物材料的理性设计，紧急性能和有前途的生物学应用的目前的进展。据信，本文可以提供使用天然功能分子作为建筑物块开发新生物材料的指导，并从材料科学的角度开始氨基糖苷的新寿命。

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  • 来源
    《Advanced Functional Materials》 |2021年第36期|2103718.1-2103718.17|共17页
  • 作者

    Hu Jingjing; Yang Lei; Cheng Xuejing; Li Yiwen; Cheng Yiyun;

  • 作者单位

    East China Normal Univ Shanghai Key Lab Regulatory Biol Shanghai 200241 Peoples R China;

    Sichuan Univ Coll Polymer Sci & Engn State Key Lab Polymer Mat Engn Chengdu 610065 Peoples R China;

    East China Normal Univ Shanghai Key Lab Regulatory Biol Shanghai 200241 Peoples R China;

    Sichuan Univ Coll Polymer Sci & Engn State Key Lab Polymer Mat Engn Chengdu 610065 Peoples R China;

    East China Normal Univ Shanghai Key Lab Regulatory Biol Shanghai 200241 Peoples R China|South China Univ Technol South China Adv Inst Soft Matter Sci & Technol Sch Mol Sci & Engn Guangzhou 510640 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    aminoglycoside; antibacterial; gene delivery; hydrogels; nanoparticles;

    机译：氨基糖苷;抗菌;基因递送;水凝胶;纳米粒子;

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