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首页> 外文期刊>Advanced Functional Materials >Use of Nanoformulation to Target Macrophages for Disease Treatment
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Use of Nanoformulation to Target Macrophages for Disease Treatment

机译：使用纳米造型测量以靶向癌症治疗巨噬细胞

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摘要

Macrophages are abundant immune cells, which serve as a primary cell population capable of interacting with foreign substances, including engineered nanomaterials (NMs). In addition to the phagocytic activity, macrophages also play a central role in innate immunity and contribute to the initiation of adaptive immunity. Since macrophages are a natural reservoir for NMs, nanoparticles (or nano-enabled strategies) are commonly utilized to target this cell type and fine tune its polarization status in different disease scenarios. In this review, a high-level description of macrophage biology is first introduced. It is followed by the discussion on the impact of therapeutic NMs on macrophages in solid tumors and how macrophages, in turn, impact the immune system and heterogeneity in the tumor microenvironment. Another major thrust is to discuss the applications of NMs in noncancer diseases with a focus on how NMs can be used to influence macrophages in the process of tissue repair, wound healing, myocardial infarction, and certain autoimmune diseases. In addition to the design of nanocarriers to impact macrophage function, whether the same response outcome can be achieved by intrinsic NM's physicochemical properties, allowing the potential usage of the active pharmaceutical ingredient-free nanomaterials for therapeutic purposes, is also discussed.
机译：巨噬细胞是丰富的免疫细胞，其用作能够与外来物质相互作用的主要细胞群，包括工程纳米材料（NMS）。除了吞噬活性外，巨噬细胞还在先天免疫力下发挥着核心作用，并有助于启动适应性免疫。由于巨噬细胞是NMS的天然储层，因此纳米颗粒（或纳米群体）通常用于靶向这种细胞类型，并在不同的疾病情景中进行微调其极化状态。在本综述中，首先介绍巨噬细胞生物学的高级描述。随后是关于治疗NMS对实体瘤中巨噬细胞的影响以及巨噬细胞的影响，反过来影响肿瘤微环境中的免疫系统和异质性。另一个主要推力是讨论NMS在非癌症疾病中的应用重点是NMS如何用于影响组织修复，伤口愈合，心肌梗塞和某些自身免疫疾病过程中的巨噬细胞。除了纳米载体的设计外，还可以通过内在的NM的物理化学性能实现相同的响应结果，允许允许潜在使用用于治疗目的的活性药物的无活性药物的纳米物质。

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  • 来源
    《Advanced Functional Materials》 |2021年第38期|2104487.1-2104487.24|共24页
  • 作者

    Liu Xiangsheng; Xie Xiaodong; Jiang Jinhong; Lin Matthew; Zheng Emily; Qiu Waveley; Yeung Iwin; Zhu Motao; Li Qinglin; Xia Tian; Meng Huan;

  • 作者单位

    Natl Ctr Nanosci & Technol CAS Ctr Excellence Nanosci CAS Key Lab Biomed Effects Nanomat & Nanosafety Beijing 100190 Peoples R China|Chinese Acad Sci Inst Basic Med & Canc IBMC Canc Hosp Univ Chinese Acad Sci Zhejiang Canc Hosp Hangzhou 310022 Zhejiang Peoples R China|Univ Chinese Acad Sci Beijing 100049 Peoples R China;

    Minjiang Univ Fuzhou Inst Oceanog Fujian 350108 Peoples R China;

    Chinese Acad Sci Inst Basic Med & Canc IBMC Canc Hosp Univ Chinese Acad Sci Zhejiang Canc Hosp Hangzhou 310022 Zhejiang Peoples R China;

    Univ Calif Los Angeles Dept Med Los Angeles CA 90024 USA;

    Univ Calif Los Angeles Dept Med Los Angeles CA 90024 USA;

    Univ Calif Los Angeles Dept Med Los Angeles CA 90024 USA;

    Univ Calif Los Angeles Dept Med Los Angeles CA 90024 USA;

    Natl Ctr Nanosci & Technol CAS Ctr Excellence Nanosci CAS Key Lab Biomed Effects Nanomat & Nanosafety Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Basic Med & Canc IBMC Canc Hosp Univ Chinese Acad Sci Zhejiang Canc Hosp Hangzhou 310022 Zhejiang Peoples R China;

    Univ Calif Los Angeles Dept Med Los Angeles CA 90024 USA;

    Natl Ctr Nanosci & Technol CAS Ctr Excellence Nanosci CAS Key Lab Biomed Effects Nanomat & Nanosafety Beijing 100190 Peoples R China|Univ Chinese Acad Sci Beijing 100049 Peoples R China;

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  • 正文语种 eng
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  • 关键词

    cancer immunotherapy; M1; M2 polarization; macrophages; nanomaterials; regenerative medicine;

    机译：癌症免疫疗法;M1;M2偏振;巨噬细胞;纳米材料;再生医学;

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