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A Multifunctional Polymeric Periodontal Membrane with Osteogenic and Antibacterial Characteristics

机译：具有成骨和抗菌特性的多功能聚合物牙周膜

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摘要

Periodontitis is a prevalent chronic, destructive inflammatory disease affecting tooth-supporting tissues in humans. Guided tissue regeneration strategies are widely utilized for periodontal tissue regeneration generally by using a periodontal membrane. The main role of these membranes is to establish a mechanical barrier that prevents the apical migration of the gingival epithelium and hence allowing the growth of periodontal ligament and bone tissue to selectively repopulate the root surface. Currently available membranes have limited bioactivity and regeneration potential. To address such challenges, an osteoconductive, antibacterial, and flexible poly(caprolactone) (PCL) composite membrane containing zinc oxide (ZnO) nanoparticles is developed. The membranes are fabricated through electrospinning of PCL and ZnO particles. The physical properties, mechanical characteristics, and in vitro degradation of the engineered membrane are studied in detail. Also, the osteoconductivity and antibacterial properties of the developed membrane are analyzed in vitro. Moreover, the functionality of the membrane is evaluated with a rat periodontal defect model. The results confirmed that the engineered membrane exerts both osteoconductive and antibacterial properties, demonstrating its great potential for periodontal tissue engineering.
机译：牙周炎是一种普遍的慢性破坏性炎症性疾病，会影响人体的牙齿支撑组织。通常通过使用牙周膜，引导组织再生策略被广泛用于牙周组织再生。这些膜的主要作用是建立防止牙龈上皮根尖迁移的机械屏障，从而使牙周膜和骨组织的生长选择性地重新填充牙根表面。当前可用的膜具有有限的生物活性和再生潜力。为了解决这些挑战，开发了包含氧化锌（ZnO）纳米粒子的骨传导，抗菌和柔性聚（己内酯）（PCL）复合膜。这些膜是通过电纺PCL和ZnO颗粒制成的。详细研究了工程膜的物理性质，机械特性和体外降解。同样，在体外分析了已开发膜的骨传导性和抗菌性能。此外，用大鼠牙周缺损模型评估膜的功能。结果证实，工程膜既具有骨传导性又具有抗菌性，证明了其在牙周组织工程中的巨大潜力。

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  • 来源
    《Advanced Functional Materials》 |2018年第3期|1703437.1-1703437.8|共8页
  • 作者

    Nasajpour Amir; Ansari Sahar; Rinoldi Chiara; Rad Afsaneh Shahrokhi; Aghaloo Tara; Shin Su Ryon; Mishra Yogendra Kumar; Adelung Rainer; Swieszkowski Wojciech; Annabi Nasim; Khademhosseini Ali; Moshaverinia Alireza; Tamayol Ali;

  • 作者单位

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Boston, MA 02139 USA|MIT, Harvard MIT Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA;

    Univ Calif Los Angeles, Sch Dent, Div Adv Prosthodont, Weintraub Ctr Reconstruct Biotechnol, Los Angeles, CA 90095 USA;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Boston, MA 02139 USA|MIT, Harvard MIT Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA|Warsaw Univ Technol, Fac Mat Sci & Engn, Mat Design Div, 141 Woloska Str, PL-02507 Warsaw, Poland;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Boston, MA 02139 USA|MIT, Harvard MIT Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA;

    Univ Calif Los Angeles, Sch Dent, Div Diagnost & Surg Sci, Los Angeles, CA 90095 USA;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Boston, MA 02139 USA|MIT, Harvard MIT Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA|Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA;

    Univ Kiel, Funct Nanomat Inst Mat Sci, Kaiserstr 2, D-24143 Kiel, Germany;

    Univ Kiel, Funct Nanomat Inst Mat Sci, Kaiserstr 2, D-24143 Kiel, Germany;

    Warsaw Univ Technol, Fac Mat Sci & Engn, Mat Design Div, 141 Woloska Str, PL-02507 Warsaw, Poland;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Boston, MA 02139 USA|MIT, Harvard MIT Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA|Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA|Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Boston, MA 02139 USA|MIT, Harvard MIT Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA|Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA|King Abdulaziz Univ, Ctr Nanotechnol, Jeddah 21569, Saudi Arabia|Konkuk Univ, Dept Bioind Technol, Coll Anim Biosci & Technol, Seoul, South Korea;

    Univ Calif Los Angeles, Sch Dent, Div Adv Prosthodont, Weintraub Ctr Reconstruct Biotechnol, Los Angeles, CA 90095 USA;

    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Boston, MA 02139 USA|MIT, Harvard MIT Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA|Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA|Univ Nebraska, Dept Mech & Mat Engn, Lincoln, NE 68588 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    electrospinning; guided tissue regeneration; osteoconductive; periodontal regeneration; zinc oxide;

    机译：电纺;引导组织再生;骨传导;牙周再生;氧化锌;

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