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首页> 外文期刊>Advanced Functional Materials >Multifaceted Implantable Anticancer Device for Potential Postsurgical Breast Cancer Treatment: A Single Platform for Synergistic Inhibition of Local Regional Breast Cancer Recurrence, Surveillance, and Healthy Breast Reconstruction
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Multifaceted Implantable Anticancer Device for Potential Postsurgical Breast Cancer Treatment: A Single Platform for Synergistic Inhibition of Local Regional Breast Cancer Recurrence, Surveillance, and Healthy Breast Reconstruction

机译：潜在的术后乳腺癌治疗的多面植入式抗癌设备：协同抑制局部区域乳腺癌复发，监测和健康的乳房重建的单一平台。

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摘要

An implantable anticancer device (IAD) amenable to eradicate local regional recurrence (LRR) of breast cancer as well as to enhance the breast reconstruction during/after therapy is proposed for the first time. The IAD is fabricated by incorporating the superparamagnetic graphene oxide doxorubicin nanocomposite of size approximate to 200 nm in a nanofiber matrix to enable the sustained and tumor specific anticancer drug release over 60 d in vitro with a minimum initial burst release and the repeated hyperthermic capability in an alternating magnetic field to ensure the synergistic inhibition of LRR. The IAD also enriches the reconstruction of poor breast cosmesis that resulted from the surgical treatment by supporting the lipofilling of the surgical residual cavity to induce the adipogenic process. Moreover, the noninvasive monitoring capability of IAD through magnetic resonance imaging augments to the effective patient care. Thus, this work reports a new and reliable concept by introducing the multifunctional IAD possessing enhanced specificity with a real-time monitoring capability and long-term anticancer efficacy as a potential platform for synergistic inhibition of LRR and a great promise for the in situ breast reconstruction ability for better breast cosmesis.
机译：首次提出了一种可根除乳腺癌的局部区域复发（LRR）以及增强治疗过程中/治疗后的乳房重建的可植入抗癌设备（IAD）。通过在纳米纤维基质中掺入大小约为200 nm的超顺磁性氧化石墨烯阿霉素纳米复合材料来制造IAD，从而能够在体外60 d内持续释放和特异于肿瘤的抗癌药物，同时具有最小的初始猝发释放和可重复的高温治疗能力。交变磁场以确保LRR的协同抑制。 IAD还通过支持手术残留腔的脂肪填充以诱导脂肪形成过程，丰富了因手术治疗而导致的乳房美容不良的重建。此外，IAD通过磁共振成像的无创监测能力增强了有效的患者护理。因此，这项工作通过引入具有增强的特异性，实时监测能力和长期抗癌功效的多功能IAD作为一种协同抑制LRR的潜在平台，报告了一个新的可靠概念，为原位乳房重建提供了广阔的前景更好的乳房美容的能力。

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